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FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β.

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第一作者： Chenxi,Gao

第一单位： Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.

作者： Chenxi,Gao ^[1] ; Guangming,Chen ^[1] ; Shih-Fan,Kuan ^[2] ; Dennis Han,Zhang ^[3] ; David D,Schlaepfer ^[4] ; Jing,Hu ^[1]

作者单位： Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States. ^[1] Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, United States. ^[2] Dietrich School of Arts and Sciences, Pittsburgh, United States. ^[3] Department of Reproductive Medicine, Moores Cancer Center, University of California, San Diego, San Diego, United States. ^[4]

关键词 FAK GSK3 PYK2 Wnt/b-catenin pathway biochemistry cell biology human intestinal tumorigenesis mouse phosphorylation

医学主题词动物(Animals);结直肠肿瘤(Colorectal Neoplasms);女(雌)性(Female);黏着斑激酶1(Focal Adhesion Kinase 1);黏着斑激酶2(Focal Adhesion Kinase 2);基因表达调控(Gene Expression Regulation);糖原合成酶激酶3(Glycogen Synthase Kinase 3);人类(Humans);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 裸(Mice, Nude)

DOI 10.7554/eLife.10072

PMID 26274564

发布时间 2022-04-08

基金项目

R01 CA102310/CA/NCI NIH HHS/United States CA102310/CA/NCI NIH HHS/United States R01 CA180769/CA/NCI NIH HHS/United States R21 CA175202/CA/NCI NIH HHS/United States CA166197/CA/NCI NIH HHS/United States R01 CA166197/CA/NCI NIH HHS/United States CA175202/CA/NCI NIH HHS/United States

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