Elevated RET expression enhances EGFR activation and mediates EGFR inhibitor resistance in head and neck squamous cell carcinoma.
第一作者:
Chengzhong,Lin
第一单位:
Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Shanghai 200011, China.
作者:
医学主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);癌, 鳞状细胞(Carcinoma, Squamous Cell);细胞周期(Cell Cycle);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);剂量效应关系, 药物(Dose-Response Relationship, Drug);抗药性, 肿瘤(Drug Resistance, Neoplasm);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);头颈部肿瘤(Head and Neck Neoplasms);人类(Humans);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);肿瘤侵润(Neoplasm Invasiveness);苯脲化合物(Phenylurea Compounds);磷酰化(Phosphorylation);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质c-ret(Proto-Oncogene Proteins c-ret);吡啶类(Pyridines);RNA干扰(RNA Interference);信号传导(Signal Transduction);时间因素(Time Factors);转染(Transfection);肿瘤负荷(Tumor Burden);增量调节(Up-Regulation);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1016/j.canlet.2016.04.023
PMID
27090738
发布时间
2021-01-02
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Cancer letters
1-10页
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