Lipophosphonoxins II: Design, Synthesis, and Properties of Novel Broad Spectrum Antibacterial Agents.-论文-万方医学网

第一作者： Gabriela,Seydlová

第一单位： Department of Genetics and Microbiology, Faculty of Science, Charles University , Viničná 5, 128 43 Prague 2, Czech Republic.

作者： Gabriela,Seydlová ^[1] ; Radek,Pohl ^[2] ; Eva,Zborníková ^[3] ; Marcel,Ehn ^[2] ; Ondřej,Šimák ^[2] ; Natalya,Panova ^[4] ; Milan,Kolář ^[5] ; Kateřina,Bogdanová ^[5] ; Renata,Večeřová ^[5] ; Radovan,Fišer ^[1] ; Hana,Šanderová ^[4] ; Dragana,Vítovská ^[4] ; Petra,Sudzinová ^[6] ; Jiří,Pospíšil ^[6] ; Oldřich,Benada ^[4] ; Tomáš,Křížek ^[7] ; David,Sedlák ^[8] ; Petr,Bartůněk ^[8] ; Libor,Krásný ^[4] ; Dominik,Rejman ^[2]

作者单位： Department of Genetics and Microbiology, Faculty of Science, Charles University , Viničná 5, 128 43 Prague 2, Czech Republic. ^[1] Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences v.v.i. , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic. ^[2] Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences v.v.i. , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.;Department of Analytical Chemistry, Faculty of Science, Charles University , Albertov 6, 128 43 Prague 2, Czech Republic. ^[3] Institute of Microbiology, Czech Academy of Sciences v.v.i. , Vídeňská 1083, 142 20 Prague 4, Czech Republic. ^[4] Department of Microbiology, Faculty of Medicine and Dentistry, Palacký University Olomouc , Hněvotínská 3, 775 15 Olomouc, Czech Republic. ^[5] Department of Genetics and Microbiology, Faculty of Science, Charles University , Viničná 5, 128 43 Prague 2, Czech Republic.;Institute of Microbiology, Czech Academy of Sciences v.v.i. , Vídeňská 1083, 142 20 Prague 4, Czech Republic. ^[6] Department of Analytical Chemistry, Faculty of Science, Charles University , Albertov 6, 128 43 Prague 2, Czech Republic. ^[7] Institute of Molecular Genetics, Czech Academy of Sciences v.v.i. , Vídeňská 1083, 142 20 Prague 4, Czech Republic. ^[8]

医学主题词动物(Animals);抗菌药(Anti-Bacterial Agents);细胞凋亡(Apoptosis);细胞系(Cell Line);细胞系, 肿瘤(Cell Line, Tumor);细胞膜(Cell Membrane);细胞存活(Cell Survival);药物设计(Drug Design);抗药性, 多种, 细菌(Drug Resistance, Multiple, Bacterial);革兰氏阴性菌(Gram-Negative Bacteria);革兰氏阳性菌(Gram-Positive Bacteria);人类(Humans);脂双层(Lipid Bilayers);男(雄)性(Male);小鼠, 近交ICR(Mice, Inbred ICR);微生物敏感性试验(Microbial Sensitivity Tests);磷脂类(Phospholipids);吡唑类(Pyrazoles);兔(Rabbits);皮肤刺激试验(Skin Irritancy Tests);立体异构现象(Stereoisomerism);构效关系(Structure-Activity Relationship);尿苷一磷酸(Uridine Monophosphate)

DOI 10.1021/acs.jmedchem.7b00355

PMID 28654257

发布时间 2018-12-30

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Lipophosphonoxins II: Design, Synthesis, and Properties of Novel Broad Spectrum Antibacterial Agents.

Journal of medicinal chemistry

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Lipophosphonoxins II: Design, Synthesis, and Properties of Novel Broad Spectrum Antibacterial Agents.

Journal of medicinal chemistry

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同项目论文

Journal of medicinal chemistry

相关期刊

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