介入栓塞治疗动脉瘤性蛛网膜下腔出血的疗效及对免疫功能的影响
Efficacy of interventional embolization in treatment of aneurysmal subarachnoid hemorrhage and its influence on immune function
目的 观察介入栓塞治疗动脉瘤性蛛网膜下腔出血(Aneurysmal subarachnoid hemorrhage,aSAH)的疗效及对免疫功能的影响.方法 选取2014年3月至2016年3月于本院接受治疗的aSAH患者85例,采用随机数字表法将其分为对照组43例与观察组42例.对照组行手术夹闭治疗;观察组行介入栓塞治疗.对比两组疗效、免疫功能、并发症情况.结果 观察组治疗总有效率高于对照组(88.10%比62.79%),差异具有统计学意义(P<0.05);术后1d,两组IgA、IgG、IgM水平均较术前下降,但观察组上述指标水平高于对照组,差异具有统计学意义(均P< 0.05);观察组脑梗死、颅内感染、肺部感染、迟发性脑血管痉挛等并发症总发生率低于对照组(9.52%比27.91%),差异具有统计学意义(P<0.05).结论 介入栓塞治疗动脉瘤性蛛网膜下腔出血疗效较佳,且对患者机体免疫功能影响较小,利于降低术后相关并发症发生.
更多Objective To observe the efficacy of interventional embolization in the treatment of aneurysmal subarachnoid hemorrhage (aSAH) and its influence on immune function.Methods 85 aSAH patients treated at our hospital from March,2014 to March,2016 were selected,and were divided into a control group(n=43) and an observation group (n=42) by random number table.The control group were treated with surgical clipping and the observation group with interventional embolization.The efficacy,immune function,and complications were compared between the two groups.Results The total effective rate was higher in the observation group than in the control group (88.10% vs.62.79%,P < 0.05).1 d after surgery,the levels of IgA,IgG,and IgM decreased in both groups,and were higher in observation group than in the control group (all P < 0.05).The total incidence of cerebral infarction,intracranial infection,pulmonary infection,and delayed cerebral vasospasm was lower in the observation group than in the control group (9.52% vs.27.91%,P < 0.05).Conclusion Interventional embolization in the treatment of aSAH is effective,has less influence on patients' immune function,and can decrease postoperative complications.
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