肺癌组织中P53和Ki-67的表达及意义
Expression and clinical significance of P53 and Ki-67 in lung cancer
目的 观察P53和Ki-67在肺癌组织中的表达状况及其与病理和临床特征的意义.方法 采用免疫组织化学SP法检测233例肺癌组织中P53和Ki-67的表达,结合临床资料进行分析.结果 肺癌组织中P53和Ki-67的阳性表达率分别为80.7%和99.6%,其中低阳性表达率分别占了阳性表达率的44.2%和57.2%.P53的表达与肺癌组织类型无明显关系,而Ki-67的表达与肺癌组织类型有一定关系,鳞癌以高表达为主,而腺癌与细支气管肺泡癌以低表达为主;P53在淋巴结转移组的阳性表达率为95.0%,高于无淋巴结转移组,而Ki-67的表达与淋巴结是否转移无明显关联.结论 肺癌组织中P53和Ki-67阳性表达率高,但低阳性表达的病例占了相当的比例,两者可能共同参与了肺癌的发生、发展,P53与肺癌淋巴结转移的关系可能更大,而Ki-67的阳性表达程度与病理类型有关.
更多Objective To investigate the expression and clinical significance of P53 and Ki-67 in lung cancer tissues.Methods The expressions of P53 and Ki-67 in 233 specimens of lung cancer were detected by SP immunohistochemistry,and were analyzed with clinical data.Results The positive expression rates of P53 and Ki-67 in lung cancer tissue were 80.7% and 99.6% respectively.In those specimens with positive expression of P53 and Ki-67,44.2% and 57.2% were low level expression respectively.There was no statistical correlation between the P53 expression and histologic type of lung cancer.Unlikely,the positive expression of Ki-67 was high in squamous carcinoma,and was low in adenocarcinoma and abronchioalveolar carcinoma. The expression rate of P53 in lung cancer with metastasis of lymphonodus was 95.0%,higher than that without metastasis.But the expression rate of Ki-67 had no relationship with metastasis of lymphonodus.Conclusions The positive expression rates of P53 and Ki-67 in lung cancer tissue are high,but nearly half are at low level.P53 and Ki-67 may involve in the occurrence and development of lung cancer. The expression rate of P53 is more relevant to metastasis of lymphonodus than that of Ki-67,while Ki-67 expression level is more relevant to histologic type of lung cancer.
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