摘要目的 用荟萃(Meta)分析的方法研究肿瘤坏死因子α(TNF-α)基因启动子区多态位点(-308 G/A)与川崎病(KD)遗传易感性的关系.方法 收集Medline和EMBASE数据库中关于TNF-α-308 G/A与KD遗传易感性的相关文献,对其进行Meta分析.结果 经数据库检索,有4篇文献纳入本研究.对等位基因和基因型频率进行分析,结果显示TNF-α-308 G/A等位基因A的频率与川崎病遗传易感性无显著相关( OR =0.836,95％CI =0.347-2.012).基因型频率与川崎病遗传易感性无显著相关(Aavs.GG,OR=0.817,95％ CI=0.292-2.284；Aavs.GA,OR=0.980,95％ CI=0.300-3.206;AA +GA vs.GG,OR=0.840,95％CI =0.356-1.981;AA+GG vs.AA,OR =0.884,95％CI=0.636-1.227).结论 TNF-α-308 G/A位点基因多态性与川崎病遗传易感性无显著相关,仍需扩大研究样本量进行分析.

abstractsObjective To determine the relationship between tumor necrosis factor-alpha (TNF-α)308G/A and Kawasaki disease susceptibility by the method of Meta-analysis.Methods All related literatures about TNF-o-308 G/A and Kawasaki disease had been collected through MEDLINE and EMBASE database,then the data were synthesized and analyzed by Meta-analysis.Results Four literatures about TNF-α-308 G/Aand Kawasaki disease were included in the study.Gene effect was assessed using per-allele and per-genotype approaches.The pooled odds ratio of A versus G was 0.836,95％ CI =0.347-2.012.The results of genotype effects indicated that the genotype of TNFA -308 G/A was not a risk factor for KD,AA vs.GG,OR =0.817,95％GI =0.292-2.284;AA vs.GA,OR =0.980,95％CI =0.300-3.206;AA +GA vs.GG,OR =0.840,95％Cl =0.356-1.981 ;AA + GG vs.AA,OR =0.884,95％ CI =0.636-1.227.Conclusion The results indicated that TNF-α-308 G/A was not associated with Kawasaki disease susceptibility.An updated Meta-analysis is needed if more studies are published.