B7家族新成员HHLA2在人类恶性肿瘤中的研究现状
The research status of a new member of B7 family HHLA2 in human malignant tumors
HHLA2(human endogenous retrovirus-H long terminal repeat-associating 2)是第二信号分子B7家族的一个新成员,与不同的受体结合提供T细胞活化的共抑制或共刺激信号.研究表明,HHLA2很少表达于人类正常组织,却高表达于多种人类恶性肿瘤组织,提示HHLA2可能参与免疫逃逸,对恶性肿瘤的发生、发展、转移及预后有一定影响,可能是恶性肿瘤免疫治疗的一个新靶点.因而,深入研究H H L A 2在多种恶性肿瘤中的表达情况有重要意义.
更多HHLA2,which is a new member of B7 family of the second signal molecules,provides coin-hibitory or costimulatory signals of the activation of T cell while binding to different receptors. Studies have shown that HHLA2 was rarely expressed in normal human tissues,but it was highly expressed in a variety of ma-lignant tumors,suggesting that HHLA2 may be involved in the immune escape and the development of malignant tumors. Thus,HHLA2 might be a potential target for tumors immunotherapy. Further research on the expression of HHLA2 in malignant tumors is of great significance.
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