检索历史 清除

组胺参与荨麻疹和特应性皮炎等常见疾病的发病机制,故抗组胺药物是皮肤科最常用的系统用药之一.已发现的四种组胺G蛋白耦联受体中,人皮肤主要表达H1和H2亚型.抗组胺药物也称为组胺受体反向激动剂,除了抗组胺作用外,同时具有不依赖于H1受体的抗炎效应.虽然抗组胺药物在临床被广泛用于治疗皮炎湿疹类疾病,但其具体机制仍不明确,证据尚有待探讨.

Antihistamines are systemically administered most widely in dermatology, which may be attributable to the important roles of histamines in common diseases such as urticaria and atopic eczema. Of the currently recognized four subtypes of G protein-coupled histamine receptors, only H1 and H2 subtypes are demonstrated to be expressed in human skin. Antihistamines, also named as H1-inverse agonists, not only have antihistamine activity but also have antiinflammatory effect independent of their actions on H1 receptors. Despite their wide use in dermatology, the action mechanism of antihistamines remains unclear, and additional studies are warranted.