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既往认为银屑病是一类慢性炎症性疾病,发病仅表现于皮肤.目前许多的研究证明,在银屑病患者群体中,某些其他疾病的发生率或风险率均较普通人群高,其中包括代谢综合征、肥胖、心血管疾病、关节炎、自身免疫性疾病、恶性肿瘤、精神疾病、肝脏疾病、慢性阻塞性肺部疾病、睡眠呼吸暂停综合征等.通过对这些合并症发病机制的研究,免疫介导的机制似乎是其诸多合并症的共同原因,但要确切了解其发病机制及有效治疗方法,须依靠多学科的有效联合和交叉研究.概述近年来银屑病合并症的流行病学研究及发病机制和治疗方法.

In the past,psoriasis was regarded as a chronic inflammatory disease limited to the skin.However,many current researches have shown that psoriasis patients,compared with the general population,are associated with a higher incidence of and risks for some other diseases,such as metabolic syndrome,obesity,cardiovascular diseases,arthritis,autoimmune diseases,malignancies,mental illnesses,liver diseases,chronic obstructive pulmonary disease (COPD),sleep apnea syndrome,etc.Immune-mediated mechanism seems to be the common causes of these comorbidities.Nevertheless,efficient collaboration among researchers across multiple disciplines is required to disclose the true pathogenesis of and develop effective treatments for these comorbidities.This article focuses on the epidemiology,mechanism and treatment of psoriasis comorbidities.