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白癜风是一种常见的色素脱失性疾病,易诊而难治.前列腺素是在紫外线照射下,角质形成细胞产生的脂类旁分泌因子,参与皮肤的免疫调节、细胞生长、分化、凋亡等生理过程.其中前列腺素E2、F2α均可不同程度地作用于黑素细胞,促进黑素细胞树突合成、黑素产生;前列腺素E2还能促进黑素细胞增殖.多项动物和临床试验已证明,局部外用前列腺素E2和前列腺素F2α治疗白癜风安全有效,因而有望成为新的治疗白癜风的药物之一.

As a common depigmentary skin disease,vitiligo is easy to diagnose but difficult to cure.Prostaglandins (PGs) are lipid paracrine factors produced by ketatinocytes in response to ultraviolet irradiation.PGs regulate many physiological processes in the skin,including immune function,cell growth,differentiation and apoptosis.Both prostaglandin E2 (PGE2) and PGF2α can stimulate dendrite formation and melanin synthesis in melanocytes.PGE2 can also promote melanocyte proliferation.Many animal and clinical trials have proved the efficacy and safety of topical PGE2 and PGF2α in the treatment of vitiligo,hence,they may serve as promising treatment options for vitiligo.