检索历史 清除

单纯疱疹病毒属双链DNA病毒,主要引起皮肤和黏膜损伤,表现为口唇疱疹、疱疹性皮炎、生殖器疱疹等.潜伏感染、周期性复发是单纯疱疹病毒的致病特性.单纯疱疹病毒感染人体后能激发人体固有和获得性免疫应答,包括固有免疫细胞、细胞因子和T淋巴细胞都参与病毒的清除;宿主细胞还可通过启动凋亡机制抑制单纯疱疹病毒的复制及扩散.但是在某些情况下,该病毒能通过潜伏感染和某些机制逃逸免疫细胞的清除,这也是单纯疱疹病毒不能根除的重要原因.为了减少病毒复发频率,已研究出一些可以作为疫苗的单纯疱疹病毒蛋白,但尚未应用于临床.因此,明确单纯疱疹病毒所诱发的机体免疫反应及其免疫逃逸机制对疾病的预防、治疗及新药研发具有重要意义.

Herpes simplex virus (HSV),a kind of double-stranded DNA virus,mainly causes cutaneous and mucosal infections which manifest as oral herpes,herpetic dermatitis,herpes genitals,and so on.Latent infection and periodical relapse are pathogenic characteristics of HSV,and repeated recurrence may lead to nerve dysfunction.After entering the human body,HSV can stimulate innate and acquired immune responses,with innate immune cells,cytokines and T lymphocytes all involved in viral clearance.In addition,host cells can also inhibit the replication and spread of virus by initiating cell apoptosis.However,in some cases,HSV can escape from the clearance of immune cells through latent infection and other mechanisms,which is an important reason why HSV cannot be completely cleared.In order to decrease the frequency of virus recurrence,some HSV proteins have been developed as vaccines,but have not been applied in clinic.Therefore,to clarify HSV-induced immune responses and mechanisms underlying its immune escape is of great significance for disease prevention,treatment and new drug development.