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自噬是进化上高度保守的溶酶体介导的分解代谢过程,可降解多种胞质内异常物质,几乎参与免疫反应的各个环节,对维持免疫系统稳定至关重要.SLE作为典型的自身免疫性疾病,存在多种免疫功能紊乱.研究证实,自噬可能通过调节免疫反应参与SLE的发生发展,且狼疮患者外周血中T、B淋巴细胞、中性粒细胞及巨噬细胞等多种免疫细胞中自噬水平均存在异常.自噬相关基因多态性与SLE易感性具有明显相关性,诱发或加重SLE的多种环境因素也可对自噬水平产生影响,部分SLE治疗药物可通过多种途径调节自噬水平.因而,自噬可能在SLE发生发展过程中发挥了重要作用.

Autophagy, a highly conserved lysosome?mediated catabolic process, is responsible for degradation of various abnormal cytoplasmic contents, participates in almost every step of immune responses, and plays a vital role in maintaining immune system homeostasis. As a typical autoimmune disease, systemic lupus erythematosus(SLE)shows multiple immunological dysfunctions. Autophagy may be involved in the initiation and progression of SLE via regulating immune responses. Actually, autophagy levels have been reported to be abnormal in multiple peripheral blood immunocytes from patients with lupus, such as T lymphocytes, B lymphocytes, neutrophils and macrophages. Furthermore, polymorphismsin autophagy?related genes are associated with SLE susceptibility. In addition, multiple environment factors which induce or exacerbate SLE may affect autophagy levles. Some drugs which are used to treat SLE can regulate autophagy via different ways. Therefore, autophagy may play an essential role in the occurrence and development of SLE.