检索历史 清除

树突细胞作为最主要的抗原提呈细胞,是连接固有免疫和适应性免疫的桥梁.树突细胞具有激活免疫应答和诱导免疫耐受的双重功能,其发挥免疫调节作用的功能与其所处的发育阶段及表型变化有着密切的关系.未成熟树突细胞具有较强的抗原摄取、处理及加工能力,抗原提呈能力弱,倾向于诱导机体免疫耐受;成熟树突细胞抗原提呈能力增强,可活化T、B淋巴细胞,倾向于激活免疫应答.髓系树突细胞主要启动和参与细胞免疫应答;而浆细胞样树突细胞则主要与体液免疫应答有关.目前认为,树突细胞成熟状态及表型变化在感染、肿瘤、自身免疫性疾病的发生发展中起着关键的作用.

As the most potent antigen ? presenting cells, dendritic cells(DCs) bridge the gap between innate and adaptive immunity. DCs can both activate immune response and induce immune tolerance. The immunoregulatory role of DCs is closely related to their development stages and phenotypic changes. Immature DCs have strong ability to uptake and process antigens,but poor ability to present antigens, and tend to induce immune tolerance. However, mature DCs have increased ability to present antigens, can activate T and B lymphocytes, and tend to activate immune response. Medullary DCs mainly initiate and participate in cellular immune response, while plasmacytoid DCs are mainly related to humoral immune response. Currently, it is considered that the maturation status and phenotypic changes of DCs play pivotal roles in the occurrence and development of infection, tumors and autoimmune diseases.