AT模体结合因子1与恶性肿瘤发生及发展相关性的研究进展
Association of ATBF1 and the growth and progression of malignant tumor
AT模体结合因子1是一个新近发现的抑癌基因,其转录本mRNA的选择性剪接产物之一,ATBF1-A能与甲胎蛋白启动子序列的AT富聚区结合,下调甲胎蛋白的表达,从而抑制肿瘤地发生、诱导肿瘤细胞凋亡.本文将通过分析近些年有关AT模体结合因子1与肿瘤发生及发展关系的文献,探讨AT模体结合因子1与其他生物因子的作用通路,揭示它多样的生物学功能,阐述AT模体结合因子1表达下调在乳腺癌、前列腺癌、胃癌等恶性肿瘤生长和侵袭产生的影响,探讨AT模体结合因子1表达水平作为一种预测指标在恶性肿瘤地应用,以及肿瘤基因治疗的前景.
更多AT motif binding factor 1 (ATBF1) gene,is a new tumor suppressor gene,and one of its expression variants by alternative splicing,known as ATBF1-A,can bind to the enhancer AT-rich element of alpha fetoprotein (AFP) and down-regulate the transcription of AFP,which may suppress the development and induce the apoptpsis of some carcinoma cells.In this review,we attempted to analysis the pathway of ATBF1 behaves with other factors and its multiple biological functions;ATBF1 function as a suppressor gene,it was illustrated for the influence on the growth and invasion of breast,prostate or gastric cancer.We also discussed the application of the ATBF1 level function as a cancer predictor,and forecasted the significance to apply ATBF1 for the therapy of cancer.
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