检索历史 清除

目的 探讨甲状腺结节(thyroid nodule,TN)患者血清抗甲状腺球蛋白抗体(thyroglobulin anti-body,TgAb)与各类甲状腺癌(thyroid cancer,TC)患病风险之间的关系.方法 TN良恶性的确定依据术后甲状腺组织常规病理活检,血清TgAb的测定采用电化学发光免疫分析法.测定2015年9月1日至2016年12月31日在郑州大学第一附属医院甲状腺外二科行手术的1 257例TN患者血清抗甲状腺球蛋白抗体(TgAb)水平.使用回顾性分析,采用Pearson x2检验等分析血清TgAb阳性者及阴性者,TN的良性率及恶性率之间的差异.结果 纳入分析的1 257例,TgAb阳性者196例,其中术后组织病理发现良性结节者94例,恶性结节者102例,良性率47.96％,恶性率52.04％;T gAb阴性者1 061例,其中术后组织病理发现良性结节者654例,恶性结节者407例,良性率61.64％,恶性率38.36％.对于PTC组,x2=23.101 9,P＜0.01,OR=1.721 8,OR的95％CI为(1.382 9,2.375 4);对于滤泡癌(follicular thyroid carcinoma,FT℃)组,连续校正的x2=0.287 5,P＞0.01;对于髓样癌(medullary thyroid carcinoma,MTC)组,P样本观察值=0.042 3,P=0.048 9＞0.01.结论 在TN患者中,检出血清TgAb阳性者患PTC的可能性大于血清TgAb阴性者,其患滤泡癌及髓样癌的风险并未检测出大于血清TgAb阴性者.

Objective To study the association between serum thyroglobulin antibody(TgAb) and the risk of thyroid cancer (TC) in patients with thyroid nodule (TN).Methods The determination of benign and malignant TN was based on routine pathological biopsy of postoperative thyroid tissues.Serum TgAb level of 1257 patients with TN undergoing surgery from 1st Sep.2015 to 31st Dec.2016 was determined by electrochemiluminescence immunoassay.A retrospective cohort analysis was performed.The correlation between the serum TgAb level and the benign or malignant rate of thyroid nodule was determined by Pearson Chi-square test.Results Among the 1257 patients,there were 196 patients whose TgAb level was high.Among these 196 patients,there were 94 patients with benign TN,with the benign rate of 47.96％ and there were 102 patients with malignant TN,with the malignant rate of 52.04％.There were also 1061 patients whose TgAb level was normal,among these 1061 patients,there were 654 patients with benign TN,with the benign rate of 61.64％ and there were 407 patients with malignant TN,with the malignant rate of 38.36％.For papillary thyroid carcinoma(PTC)patients,x2=23.101 9,OR=1.7218,the 95％ CI of OR was(1.382 9,2.375 4).For follicular thyroid carcinoma(FTC) patients,x2=0.287 5,P＞0.01.For medullary thyroid carcinoma (MTC) patients,P=0.048 9＞0.01.Conclusions Among patients with TN,PTC rate of the patients whose serun TgAb level is high is higher than patients whose serum TgAb level is normal.But among the patients with TN,we do not think that FTC and MTC rate of patients whose serun TgAb level is high is higher than patients whose serum TgAb level is normal.