全氟及多氟类化合物与人类生殖关系的研究进展
Research progress of the relationship between perfluoroalkyl and polyfluoroalkyl substances and human reproduction
全氟和多氟烷酸类化合物(PFASs)是一类在环境和生物体内广泛存在、具有广泛毒性的环境内分泌干扰物(EEDs),其中研究最多的是全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA).已有大量实验和流行病学调查结果表明,PFASs暴露与人类生殖健康有关.本文针对PFASs对人类生殖力,包括与生殖细胞发生发育、生殖激素分泌调节、出生子代健康等关系进行阐述,并对目前PFASs有关研究所存在的问题及今后的研究方向进行讨论和展望.
更多Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are a group of environmental endocrine disruptors (EEDs) that are widespread in the environment and organisms,including perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA).A large number of experimental and epidemiological investigations have shown that PFASs exposure is associated with disorders of human reproduction.The present review focuses on the effect of PFASs on the human reproduction,including their associations with the development of germ cells,the secretion of reproductive hormone,the health of the offspring and so on.The problems and prospect in the research of PFASs have been discussed.
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