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目的 探讨血清同型半胱氨酸(HCY)和高敏C反应蛋白(hs-CRP)在心血管疾病(CVD)诊疗中的临床价值.方法 通过临床试验,检测210例CVD患者和190名健康人群中血清HCY浓度,同时检测hs-CRP,进行对比分析.结果 CVD患者组(试验组)的血清HCY浓度主要集中在10～20 μ mol/L,而健康体检者(对照组)则为0～5μmol/L;试验组的血清hs-CRP浓度主要集中在2～15 mg/L,而对照组则为0～8 mg/L;试验组HCY浓度平均值为19.6μmol/L,明显高于对照组的9.4μmol/L,而试验组hs-CRP浓度平均值为8.4 mg/L,也明显高于对照组的1.3 mg/L,两组在血清HCY和hs-CRP这两项指标上存在高度一致性,且数据集中趋势比较明显.结论 综合监测血清中HCY和hs-CRP浓度的变化,对心血管疾病诊疗有十分重要的临床价值.

Objective Discuss the clinical value of serum homocysteine (HCY) and highsensitivity C-reactive protein (hs-CRP) in the diagnosis and treatment of cardiovascular disease (CVD).Methods Through the clinical test,the serum HCY concentration and hs-CRP concentration of 210 cases of CVD patients and 190 cases of healthy peoples were tested and compared.Results For serum HCY,the CVD patient group (experimental group) concentrate mainly on the range of 10-20 μ mol/L,and healthy group (control group) concentrate mainly on the range of 0-5 μ mol/L,for serum hs-CRP,the concentration of the experimental group concentrate mainly on the range of 2-15 mg/L,while the concentration of the control group concentrate mainly on the range of 0-8 mg/L,the average concentration of experimental group HCY is 19.6 μ mol/L,significantly higher than 9.4 μ mol/L of control group;the average concentration of experimental group hs-CRP is 8.4 mg/L,significantly higher than 1.3 mg/L of control group,there is a high degree of consistency in serum HCY and hs-CRP of two groups,and the central tendency of the data is more obvious.Conclusion Through comprehensive monitoring of serum HCY and hs-CRP concentration,it has important clinical value for the diagnosis and treatment of cardiovascular disease.