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目的：探讨血清胱抑素C水平与遗忘型轻度认知功能障碍（aMCI）的关系。方法选取2011年8月至2013年8月郑州大学附属洛阳中心医院收治的神经内科患者249例，分为aMCI组165例与对照组84例，对其进行年龄、性别，文化程度，吸烟、饮酒史，有无糖尿病、高血压、血脂水平、肌酐水平以及脑血管病记录，检测血清胱抑素C水平、认知功能评分，调整可能的影响因素，分析血清胱抑素C水平与aMCI发生的相关性。结果不同Cys-C水平组中年龄、高血压、糖尿病、吸烟、饮酒、血脂异常、肌酐结果异常情况分布差异有统计学意义（P<0.05）；aMCI组血清Cys-C水平与对照组差异有统计学意义（P<0.05）。aMCI组血清Cys C水平与MMSE得分（r=-0.319）、MOCA得分（r=-0.583）及MOCA分项中的视空间与执行能力（r=-0.301）、命名能力（r=-0.265）、注意能力（r=-0.254）和延迟回忆能力（r=-0.239）的得分均存在负相关（P<0.05），随着血清Cys-C水平的升高，aMCI患病的发生率升高（χ2=14.23，P<0.01）；不同血清Cys-C水平患者aMCI患病风险的多因素Logistic回归分析显示高血清Cys-C水平、糖尿病史、受教育年限、饮酒史、血脂异常是导致aMCI的独立危险因素；结论 Cys-C水平升高是aMCI的危险因素。

Objective To investigate the association of Cys-C level and forget pattern mild cognitive impairment and analyze the risk factors for aMIC. Methods Proceed the age, sex, standard of culture, the history of smoking and drinking, diabetes, blood fat, creatinine, high biood pressure, cerebral blood disease, the level of Cys-C and the level of cognitive impairment for 249 effective case about aMCI group and control group. Arrange the possible influence factor, investigate the affect between Cys-C level and forget pattern mild cognitive impairment. Results 0 in defferent Cys-C level, the distribution of age, standard of culture, the history of smoking and drinking, diabetes, high biood pressure, anomaly blood fat, anomaly creatinine are significant difference(P<0.05)the level of Cys-C in aMCI group and control group are significant difference(P<0.05). The level of Cys-C aMCI group and MMSE(r=-0.319),MOCA (r=-0.583), and score visuospatial executive(r=-0.301), naming(r=-0.265), attention(r=-0.254), delayed recall of MOCA(r<0, P<0.05),The level of Cys-C raising,incidence of aMCI increasing(χ2=14.23, P<0.01);Logistic regression analysis shoud different level of Cys-C、standard of culture ,the history of smoking and drinking, diabetes , blood fat,are the single risk for aMCI. Conclusion The high Cys-C level is a risk factor for aMIC.