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目的：研究不同强度高能聚焦超声治疗中晚期胰腺癌的效果。方法回顾性分析2007年3月至2013年3月太原市中心医院超声刀科单纯应用FEP-BY02型高能聚焦超声治疗的中晚期胰腺癌患者67例，观察应用不同强度的高能聚焦超声热强度后的镇痛效果、生存质量。结果取高能聚焦超声热强度100～300 W治疗后1周、1个月、3个月疼痛缓解率分别为58.1%、47.3%、36.8%，生存质量有所改善；取高能聚焦超声热强度300～500 W治疗后1周、1个月、3个月疼痛缓解率分别为65.5%、72.4%、44.8%，生存质量明显改善；取高能聚焦超声热强度500～600 W治疗后1周、1个月、3个月疼痛缓解率分别为68.4%、73.3%、42.2%，生存质量也明显改善。治疗强度为500～600W时出现8例入射处皮肤起水泡及9例点状碳化。结论对于中晚期胰腺癌患者，在应用高能聚焦超声热剂量为400～500 W治疗时就能达到减轻疼痛、提高生存质量的效果。高能聚焦超声热剂量500～600 W与400～500 W比较治疗效果无明显差别。

Objective To study the different strength of high intensity focused ultrasound in treatment of advancedpancreatic cancer effect. Methods Retrospective analysis of 2007 March to 2013 March in 67 cases of advanced pancreatic cancer patients in our treatment center the simple application of FEP-BY02 type high-intensity focused ultrasound therapy, quality of life, the analgesic effect of high intensity focused ultrasound thermal intensityobserved by different intensity of. Results High intensity focused ultrasound thermal strength after 100~300 W treatment one week, one month, there months of pain relief rate was 58.1%, 47.3%, 36.8%, quality of life improved;thehigh intensity focused ultrasound thermal strength after 300~500 W treatment one week, one month, there months ofpain relief rate was 65.5%, 72.4%, 44.8%quality of life was improved;take, high intensity focused ultrasound thermalstrength after 500~600 W treatment one week, one month, there months of pain relief rate was 68.4%, 73.3%, 42.2%, quality of life is improved obviously. The intensity of therapy for 500~600 W appearance of 8 cases of incident at the skinblisters and 9 cases of punctate carbonization. Conclusion For the patients with advanced pancreatic cancer, in theapplication of high-intensity focused ultrasound thermaldose of 400~500 W treatment can relieve pain, improve life quality effect. High intensity focused ultrasound thermaldose of 500~600 W compared with 400~500 W treatment had no significant difference.