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目的 探讨血必净治疗创伤性脑损伤后肺损伤的效果.方法 构建创伤性脑损伤后肺损伤的大鼠模型90例,按照随机分组法分为生理盐水组、TBI模型组及血必净干预组三组,每组30例.统计分析三组炎症因子C反应蛋白的情况.结果 治疗24 h时,生理盐水组、TBI模型组及血必净干预组大鼠炎症因子C反应蛋白水平分别为(64.42±13.22)mg/L、(63.85±14.36)mg/L及(63.83±13.51)mg/L,三组比较差异无统计学意义(P>0.05);治疗7、14及21 d时,血必净干预组大鼠炎症因子C反应蛋白水平分别为(31.52±10.02)mg/L、(21.35±9.54)mg/L及(13.14±3.06)mg/L,明显优于生理盐水组及TBI模型组,差异有统计学意义(P<0.05).结论 运用血必净治疗创伤性脑损伤后肺损伤,可显著改善炎症因子C反应蛋白水平,可进行有效普及推广.

Objective To investigate the application value of Xuebijing in treatment of lung injury after traumatic brain injury. Methods A total of 90 rats with traumatic brain injury models were estab-lished and randomly divided into the physiological saline group,TBI model group and Xuebijing intervention group,with 30 cases in each group. The inflammatory factor C-reactive protein was statistically significantly analyzed. Results After 24 hours of treatment,the inflammatory factor C-reactive protein in the physiologi-cal saline group,TBI model group and Xuebijing intervention group were(64. 42 ± 13. 22)mg/L,(63. 85 ± 14. 36)mg/L and(63. 83 ± 13. 51) mg/L,and there was no statistically significant difference between the three groups( P >0. 05 ) . The inflammatory factor C-reactive protein in the Xuebijing intervention group were(31.52 ±10.02)mg/L at Day 7,(21.35 ±9.54)mg/L at Day 14 and(13.14 ±3.06)mg/L at Day 21,which were significantly better than those in the physiological saline group and TBI model group( P<0. 05). Conclusion Xuebijing in treatment of lung injury after trauma brain injury can significantly im-prove the level of inflammatory factor C-reactive protein,which is worth to be clinical promoted.