摘要目的 探讨冬季妊娠中期孕妇的25-羟维生素D[25(OH)D]营养状况及其与孕妇年龄、血红蛋白水平的相关关系。方法 选取2009年12月至2010年2月在南京医科大学第一附属医院就诊的78名正常妊娠中期孕妇为研究对象。于孕24 ～ 28周取空腹静脉血，检测血清25(0H)D和全血血红蛋白水平。采用Pearson相关分析研究血清25(OH)D水平与孕妇年龄、血红蛋白水平的相关性。结果 冬季妊娠中期孕妇25(OH)D缺乏(≤25.0 nmol/L)的发生率为65.38％，25(OH)D不足[25.0 nmol/L＜25 (OH)D≤50.0 nmol/L]的发生率为30.77％，25(OH)D正常者占3.85％。冬季妊娠中期孕妇血清25(OH)D水平与血红蛋白水平呈正相关(r=0.2746,P=0.015)。结论 冬季妊娠中期孕妇普遍存在25(OH)D不足或缺乏，低血红蛋白水平的孕妇尤甚。

abstractsObjective To investigate the serum concentration of 25-hydroxy vitamin D [25(OH)D] in the second-trimester women in winter and explore its correlation with age and blood hemoglobin level. Methods The blood samples of 78 second-trimester women were collected during the 24-28 gestational weeks. Serum 25 (OH) D and blood hemoglobin levels were measured. The correlations of serum 25 (OH) D with age and blood hemoglobin levels were analyzed by Pearson correlation. Results Of the 78 pregnant women, the rates of vitamin D deficiency ( ≤25.0 nmol/L), insufficiency [25.0 nmol/L ＜ 25(OH) D≤50.0 nmol/L], and sufficiency were 65.38％, 30.77％, and 3.85％, respectively. Serum concentration of 25 (OH) D was positively correlated with blood hemoglobin level ( r =0.2746, P =0.015 ). Conclusion Vitamin D deficiency or insufficiency is common among the second-trimester women in winter, especially among those with low hemoglobin level.