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目的 探讨糖尿病患者CEA水平与VEGF的相关性.方法 收集92例住院糖尿病患者(根据强化治疗分为DM强化治疗前组和DM强化治疗后组)和94例健康体检者(对照组).检查入组患者的CEA、HbAlc和VEGF等相关指标,比较糖尿病患者和健康体检者的CEA和VEGF水平并分别计算其相关性.结果 DM强化治疗前组CEA和VEGF均显著高于强化治疗后组和对照组;DM强化治疗后组CEA和VEGF也显著高于对照组;HbAlc和VEGF与CEA均呈正相关(r=0.91,P＜0.05,r =0.90,P＜0.05),而强化治疗后的VEGF与HbAlc不相关(r=0.17,P＞0.05).结论 糖尿病患者的CEA与VEGF水平呈正相关,VEGF可能是糖尿病患者CEA升高的机制之一.

Objective To investigate the correlation between serum carcinoembryonic antigen (CEA) levels and vascular endothelial growth factor (VEGF) levels in diabetics.Methods 92 cases of hospitalized diabetics (they were divided into the pre-treatment group and after-treatment group by intensive hypoglycemic treatment) were collected,and 94 cases of healthy controls were chosen as control group.Serum levels of CEA,hemoglobin Alc (HbAlc),VEGF and another indicators were detected and compared among the three groups.The correlations between VEGF,CEA,and HbA1c were analyzed respectively.Results The serum levels of CEA and VEGF in pre-treatment group were significantly higher than that in after-treatment group and healthy control group.In diabetics,the CEA level was positively correlated with HbA1 c (r =0.91,P ＜ 0.05) and VEGF (r =0.90,P ＜ 0.05),while there was no correlation between HbA1 c and VEGF after intensive treatment (r =0.17,P ＞ 0.05).Conclusions The level of VEGF was positively correlated with CEA,and VEGF maybe one of the pathogenesis of high CEA in diabetes mellitus.