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Signaling transduction by IgG receptors

摘要:

Objective To review and summarize literature regarding stimulatory and inhibitory signaling pathways from different types of Fc gamma receptors (FcγRs).Data source Articles were obtained from Medline from January 1991 to April 2002. Study selection Over 100 English language papers and reviews published over the last 11 years were selected.Results and Conclusions Stimulatory Fcγ receptors include FcγRI, FcγRIIA, FcγRIIC, and FcγRIII A. They transduce signals through the immunoreceptor tyrosine-based activation motif (ITAM) in subunits or in the cytoplasmic domain. Inhibitory Fcγ receptors, such as FcγRIIB, are single chain receptors, transducing signals through an immunoreceptor tyrosine-based inhibitory motif (ITIM) in cytoplasmic domains. Stimulatory signals include protein phosphorylation, increase in intracellular free calcium, the production of 1,4,5-triphosphate inositol (IP3) and diacylglycerol (DAG) mainly through the Src-family kinases, phosphoinositide 3-kinase (PI3-K) and phospholipase C (PLC). Inhibitory signaling has been implicated in the repression of the above activities as well as inhibition of B cell responses through Src homology 2-containing inositol phosphatase (SHIP).

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作者: 潘銮凤 [1] 裴鹏 [1]
作者单位: Laboratory of Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China [1]
期刊: 《中华医学杂志(英文版)》2003年116卷4期 487-494页 SCISCIEMEDLINEISTICCSCDCABP
分类号: R55
栏目名称: REVIEW ARTICLES
发布时间: 2004-01-08
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