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Type ⅡB human skeletal muscle fibers positively correlate with bone mineral density irrespective to age

摘要:

Background Age-associated decrease in type ⅡA/B human skeletal muscle fibers was detected in human biopsies in our previous study. The relationship between change in muscle fiber typing and bone mineral density (BMD) is, however,unknown either cross-sectionally or longitudinally. We therefore conducted a cross-sectional study to investigate their correlation using human muscle biopsies.Methods Forty human subjects aged (53.4±20.2) years were recruited. Histomorphometric parameters of their muscle biopsies were measured by ATPase staining and image analysis, including average area percentage, fiber number percentage, mean fiber area, and area percentage of connective tissues. Hip and spine BMD was measured by dual-energy X-ray absorptiometry. Partial correlation with adjusting age was performed.Results Type ⅡB muscle fiber was found positively correlated with hip BMD irrespective to age and demonstrated significantly stronger relationship with BMD among all fiber types, in terms of its cross-sectional area (r=0.380, P=0.029)and size (r=0.389, P=0.025). Type ⅡA muscle fibers associated with hip BMD in mean fiber area only (r=0.420, P=0.015).Conclusions Type ⅡB muscle fiber may play an important role in maintaining bone quality. This may also be a relatively more sensitive fiber type of sarcopenia and osteoporosis. These findings further consolidate the muscle-bone relationship.

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作者单位: Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China [1]
期刊: 《中华医学杂志(英文版)》2010年123卷21期 3009-3014页 SCISCIEMEDLINEISTICCSCDCABP
分类号: R5
DOI: 10.3760/cma.j.issn.0366-6999.2010.21.011
发布时间: 2010-12-13
基金项目:
Direct Grant, The Chinese University of Hong Kong
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