Effects of diabetes mellitus on prognosis of the patients with colorectal cancer undergoing resection: a cohort study with 945 patients
Background Diabetes mellitus plays an important role in cancer prevalence and outcomes. The aim of this study was to evaluate the influence of DM on stages and outcomes among patients with colorectal cancer.Methods The study enrolled 945 patients who were diagnosed as having colorectal carcinoma from August 1994 to December 2002. In the cohort, 26 patients were diagnosed as having DM. With a median follow-up of 45.8 months,differences in overall survival and disease-free survival between the diabetes and non-diabetes groups were analyzed.Results Kaplan and Meier analysis showed that there were no significant differences between the two groups in overall survival rates at 3 years or 5 years. At 5 years, patients with DM, compared with patients without diabetes, experienced a significantly lower disease-free survival rate (34.2% diabetics vs. 55.1% non-diabetics; P=0.025).Conclusions DM was associated with an increased risk of recurrence in patients with colorectal cancer.
|作 者||CHEN Chuang-qi；FANG Le-kun；CAI Shi-rong；MA Jin-ping；YANG Guang-xin；YANG Wan；ZHAN Wen-hua；HE Yu-long|
|刊 名||中华医学杂志（英文版） 2010年123卷21期 3084-3088页|
|英文期刊名||CHINESE MEDICAL JOURNAL|
|关键词||colorectal cancer diabetes mellitus survival rate|
|基金项目||the Science and Technology Program of Guangdong Province, China(项目编号：2009B030801144)National College of Innovative Experimental Projects for Sun Yat-sen University Students(项目编号：2008051)Guangdong Province College of Innovative Experimental Projects(项目编号：1055810120)|