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首页 > 中华医学杂志(英文版) >A follow-up study of women with a history of severe preeclampsia: relationship between metabolic syndrome and preeclampsia

A follow-up study of women with a history of severe preeclampsia: relationship between metabolic syndrome and preeclampsia

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Background Women with a history of preeclampsia have twice the risk of cardiovascular diseases, and there is a graded relationship between the severity of preeclampsia and the risk of cardiac disease. Moreover, metabolic scores are associated with developing preeclampsia. However, since there are no diagnostic criteria for metabolic syndrome during pregnancy and pregnant women undergo metabolic changes, it is difficult to elucidate the relationship between preeclampsia and metabolic syndrome. We carried out a cross-sectional study to investigate the relationship between metabolic syndrome and preeclampsia among women with a history of severe preeclampsia shortly after an indexed pregnancy.Methods We recruited 62 women with a history of severe preeclampsia 1 to 3 years after an indexed pregnancy. Blood pressure and body compositional indices were recorded. Fasting blood samples were tested for glucose, total cholesterol,high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, triglycerides, and insulin. A questionnaire was used to collect demographic data including pre-pregnancy weight and family history of diseases associated with cardiovascular diseases. Criteria for metabolic syndrome were defined by the National Cholesterol Education Program,Adult Treatment Panel Ⅲ 2001 (NCEP Ⅲ) and International Diabetes Federation 2005 (IDF). Data were analyzed by the α2 test and multivariate Logistic regression.Results According to NCEP Ⅲ and IDF standards, 17 (27%) and 24 (39%) women, respectively, were identified as having metabolic syndrome. Being overweight pre-pregnancy and currently overweight were risk factors, and currently overweight was an independent risk factor. A combination of blood pressure and waist circumference was predictive of metabolic syndrome with a sensitivity of 91.67% and specificity of 94.74%.Conclusions An unfavorable metabolic constitution in women may lead to metabolic syndrome, preeclampsia, and long-term cardiovascular disease. In women with severe preeclampsia, therapeutic interventions should include weight-control shortly after pregnancy, especially among women who were previously overweight.

作 者 LU Jie(Department of Gynecology & Obstetrics, Peking University Third Hospital, Beijing 100191, China);ZHAO Yang-yu(Department of Gynecology & Obstetrics, Peking University Third Hospital, Beijing 100191, China);QIAO Jie(Department of Gynecology & Obstetrics, Peking University Third Hospital, Beijing 100191, China);ZHANG Hong-jun(Department of Gynecology & Obstetrics, Peking University Third Hospital, Beijing 100191, China);GE Lin(Department of Gynecology & Obstetrics, Peking University Third Hospital, Beijing 100191, China);WEI Yuan(Department of Gynecology & Obstetrics, Peking University Third Hospital, Beijing 100191, China);
刊 名 中华医学杂志(英文版)  2011年124卷05期 775-779页  科学引文索引(Science Citation Index)收录科学引文索引扩展版(SCI Expanded)收录美国国立医学图书馆Medline数据库收录美国生物学预评数据库(BIOSIS Previews)收录美国《化学文摘》(Chemical Abstracts)收录中国科技论文统计源期刊(中国科技核心期刊)收录
英文期刊名 CHINESE MEDICAL JOURNAL
关键词 metabolic syndrome severe preeclampsia cardiovascular disease
分类号 R3
DOI号 10.3760/cma.j.issn.0366-6999.2011.05.026

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