登录 |  注册 |  忘记密码 |  购卡 |  公司首页
简体   繁體   English
首页 > 中华医学杂志(英文版) >A multivariate analysis of prognostic determinants for stages Ⅱ and Ⅲ colorectal cancer in 141 patients

A multivariate analysis of prognostic determinants for stages Ⅱ and Ⅲ colorectal cancer in 141 patients

    加入收藏夹      点击:49

Background Previous prognosis analyses of colorectal cancer (CRC) patients with stage Ⅱ and Ⅲ disease were done as separate categories. The purpose of this study was to analyze prognostic factors associated with survival in a group of patients who underwent radical resection of stages Ⅱ and Ⅲ CRC.Methods A retrospective review was performed for 141 consecutive stages Ⅱ and Ⅲ patients who had undergone radical resection of coloractal adenocarcinoma between May 2003 and November 2003. Univariate and multivariate analyses were performed to assess the effect of record variables on disease free survival and overall survival.Results The median follow-up time was 59 months, and the 3-and 5-year survival rates were 76% and 68%,respectively. Four factors were independently associated with a worse disease-free survival: diabetes (hazard ratio (HR) 2.338; 95% confidence interval (CI) 1.011-5.407), expression of cyclooxygenase-2 (Cox-2) (HR 0.335; 95% CI 0.126-0.888), expression of matrix metalloproteinases 2 (MMP-2) (FIR 0.233; 95% CI 0.101-0.541), expression of vascular endothelial growth factor (VEGF) (HR 0.295; 95% CI 0.088-0.996). Four factors were independently associated with a worse overall survival: lymph nodes metastasis (HR 1.67; 95% CI 1.29-2.14), Cox-2 positive (HR 0.056; 95% CI 0.247-0.731), MMP-2 positive (HR 0.398; 95% CI 0.190-0.836), VEGF (HR 0.364; 95% CI 0.090-0.716).Conclusions Diabetes, expression of Cox-2, MMP-2 and VEGF were independently associated with a worse diseasefree survival. Lymph nodes metastasis, expression of Cox-2, MMP-2 and high level of VEGF predicted a poor overall survival.

作 者 ZHOU Zhong-guo;WU Xiao-jun;LI Li-ren;PENG Zhi-heng;DING Pei-rong;WANG Ruo-jing;PAN Zhi-zhong
刊 名 中华医学杂志(英文版)  2011年124卷14期 2132-2135页  科学引文索引(Science Citation Index)收录科学引文索引扩展版(SCI Expanded)收录美国国立医学图书馆Medline数据库收录美国生物学预评数据库(BIOSIS Previews)收录美国《化学文摘》(Chemical Abstracts)收录中国科技论文统计源期刊(中国科技核心期刊)收录
英文期刊名 CHINESE MEDICAL JOURNAL
关键词 colorectal cancer stage Ⅱ stage Ⅲ prognosis
分类号 Q939.139
基金项目 the Guangdong Scientific Planning Project(项目编号:2008B030301119)Guangdong Medical Research Funds(项目编号:B2007071;B2008057)
DOI号 10.3760/cma.j.issn.0366-6999.2011.14.010

特别提示:本网站仅提供医学学术资源服务,不销售任何药品和器械,有关药品和器械的销售信息,请查阅其他相关网站。

北京万方数据股份有限公司

万方数据电子出版社

关于我们  |   联系我们  |   网站地图  |   主要产品  |   主要服务

使用帮助  |   服务承诺  |   诚聘英才  |   友情链接  |   知识产权

客服热线:4000-115-888 转3 (周一至周五:8:00至17:00)

客服邮箱:yiyao@wanfangdata.com.cn

充值卡购卡热线:400-667-1808

互联网出版许可证 新出网证(京)字042号

互联网药品信息服务资格证书号:(京)-经营性-2011-0017

信息网络传播视听节目许可证

北京市公安局海淀分局备案号:110109081585

京ICP证010071号