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首页 > 中华医学杂志(英文版) >Cytokeratin 19 fragment antigen 21-1 as an independent predictor for definitive chemoradiotherapy sensitivity in esophageal squamous cell carcinoma

Cytokeratin 19 fragment antigen 21-1 as an independent predictor for definitive chemoradiotherapy sensitivity in esophageal squamous cell carcinoma

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Background Patients with esophageal squamous cell carcinoma (ESCC) undergoing definitive chemoradiotherapy (CRT) seem to have a disparity in therapeutic response.The identification of CRT sensitivity-related clinicopathological factors would be helpful for selecting patients most likely to benefit from CRT.Cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) and carcinoembryonic antigen (CEA) have been reported as useful tumor markers for esophageal cancer.The aim of this study was to examine the predictive value of CYFRA21-1 in comparison with CEA and other clinicopathological factors in patients with ESCC treated with definitive CRT.Methods Pretreatment serum CYFRA21-1 and CEA levels were measured by immunoradiometric assays.The relationships between pretreatment clinicopathological factors and the efficacy of CRT were analyzed.Overall survival (OS) was estimated by univariate and multivariate analysis.Results The results from a univariate analysis indicated that the efficacy of CRT was significantly associated with the serum levels of CYFRA21-1 and CEA before treatment (P=0.001 and P=0.023,respectively).It also indicated that the efficacy of CRT was significantly associated with the pretreatment tumor location (P=0.041).By Logistic regression analysis,the independent predictive factor associated with efficacy of CRT was CYFRA21-1 (P=0.002).The OS of the patients with high CYFRA 21-1 levels was worse than that of those with low CYFRA21-1 levels (P=0.001).In multivariate analysis,a low level of CYFRA21-1 was the most significant independent predictor of good OS (P=0.007).Conclusions CEA and tumor location may be useful in predicting the sensitivity of ESCC to CRT.CYFRA21-1 may be an independent predictor for definitive CRT sensitivity in ESCC.

作 者 YAN Hong-jiang(Department of Radiation Oncology, Shandong Tumor Hospital,Shandong Province Key Laboratory of Medical Health for Radiation Oncology, Shandong Academy of Medical Sciences,Jinan, Shandong 250117, China);WANG Ren-ben(Department of Radiation Oncology, Shandong Tumor Hospital,Shandong Province Key Laboratory of Medical Health for Radiation Oncology, Shandong Academy of Medical Sciences,Jinan, Shandong 250117, China);ZHU Kun-li(Department of Radiation Oncology, Shandong Tumor Hospital,Shandong Province Key Laboratory of Medical Health for Radiation Oncology, Shandong Academy of Medical Sciences,Jinan, Shandong 250117, China);JIANG Shu-mei(Department of Radiation Oncology, Shandong Tumor Hospital,Shandong Province Key Laboratory of Medical Health for Radiation Oncology, Shandong Academy of Medical Sciences,Jinan, Shandong 250117, China);ZHAO Wei(Department of Radiation Oncology, Shandong Tumor Hospital,Shandong Province Key Laboratory of Medical Health for Radiation Oncology, Shandong Academy of Medical Sciences,Jinan, Shandong 250117, China);XU Xiao-qing(Department of Radiation Oncology, Shandong Tumor Hospital,Shandong Province Key Laboratory of Medical Health for Radiation Oncology, Shandong Academy of Medical Sciences,Jinan, Shandong 250117, China);FENG Rui(Department of Radiation Oncology, Shandong Tumor Hospital,Shandong Province Key Laboratory of Medical Health for Radiation Oncology, Shandong Academy of Medical Sciences,Jinan, Shandong 250117, China);
刊 名 中华医学杂志(英文版)  2012年125卷08期 1410-1415页  科学引文索引(Science Citation Index)收录科学引文索引扩展版(SCI Expanded)收录美国国立医学图书馆Medline数据库收录美国生物学预评数据库(BIOSIS Previews)收录美国《化学文摘》(Chemical Abstracts)收录中国科技论文统计源期刊(中国科技核心期刊)收录
英文期刊名 Chinese Medical Journal
关键词 esophageal squamous cell carcinoma chemoradiotherapy cytokeratin 19 fragment antigen 21-1 carcinoembryonic antigen
分类号 R3
DOI号 10.3760/cma.j.issn.0366-6999.2012.08.009

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