• 医学文献
  • 知识库
  • 评价分析
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
  • 临床诊疗知识库
  • 中医药知识库
  • 机构
  • 作者
热搜词:
换一批
论文 期刊
取消
高级检索

检索历史 清除

医学文献 >>
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
知识库 >>
  • 临床诊疗知识库
  • 中医药知识库
评价分析 >>
  • 机构
  • 作者
热搜词:
换一批

免疫清除期慢性乙型肝炎肝脂肪变与血清病毒学指标关系

Relationship between liver steatosis and serum virological markers during immune clearance phase of chronic hepatitis B

摘要:

目的 探讨处于免疫清除(immune clearance ,IC)期的CHB患者肝脂肪变与血清病毒学指标的关系.方法 2009年1月至2016年10月福建医科大学附属第一医院肝病中心根据肝穿刺病理诊断为IC期的CHB患者,根据肝脏脂肪变程度,分为无或轻度脂肪肝(F0~1)组和中重度脂肪肝(F2~4)组,比较肝细胞脂肪变与其血清病毒学指标关系.计量资料采用独立样本 t检验,计数资料采用卡方检验.结果 298例患者纳入研究,男237例,女61例,年龄(32 .3 ± 10 .3)岁,肝脂肪变发生率为23 .5%(70/298) .其中F0~F1组273例(91 .6%) ,F2~ F4组25例(8 .4%) . F2~ F4组体质指数、血清三酰甘油、总胆固醇分别为(25 .90 ± 2 .70) kg/m2、(1 .52 ± 0 .77) mmol/L 、(4 .88 ± 1 .15) mmol/L ,高于F0~F1组的(21 .68 ± 2 .90) kg/m2、(1 .11 ± 0 .55) mmol/L 、(4 .33 ± 0 .92) mmol/L ,比较差异均有统计学意义(t值分别为-7 .007 、-2 .667和-2 .751 ,均 P<0 .05) .同时 HBsAg 、HBV DNA F2~F4组也高于F0~1组,比较差异均有统计学意义(t值分别为 -3 .291和-2 .831 ,均 P<0 .01) .根据在炎症及纤维化程度分级后发现,F0~F1与F2~F4组间 HBsAg 、HBV DNA的水平只有在炎症程度较重(t值分别为-2 .738和-2 .135)或纤维化程度较轻(t值分别为 -2 .258和 -2 .333)的患者中差异有统计学意义(均 P<0 .05) .结论 IC期CHB患者肝脏脂肪变性的严重程度与血清 HBsAg及 HBVDNA水平呈正比,这种现象与肝脏炎症程度密切相关.

更多
abstracts:

Objective To investigate the relationship between hepatic steatosis and virological markers in patients with chronic hepatitis B (CHB ) during immune clearance (IC ) phase.Methods Pathology proven CHB patients in IC phase were collected from the Liver Center of the First Affiliated Hospital of Fujian Medical University from January 2009 to October 2016 .Patients were divided into non-to mild fatty liver (F0 -F1) group and moderate to severe fatty liver (F2 -F4) group according to the liver steatosis degree .The relationship between liver steatosis and virological markers in serum was compared .The measurement data were analyzed using independent sample t test ,and the count data were analyzed by chi-square test .Results A total of 298 patients were included ,including 237 males (79 .5%) and 61(20 .5%) females ,and the average age was (32 .4 ± 10 .3) years old .The 23 .5%(70/298) of these patients had liver steatosis .A total of 273 (91 .6%) cases were in F0-F1 group ,and the remaining 25 (8 .4%) cases were in F2 -F4 group.The patients in F2 - F4 group had higher body mass index ([25.90 ± 2.70] vs [21 .68 ± 2.90] kg/m2) ,serum triglyceride ([1.52 ± 0.77] vs [1.11 ± 0.55] mmol/L) and cholesterol ([4 .88 ± 1 .15] vs [4 .33 ± 0 .92] mmol/L) than F0-F1 group ,and the differences were all statistically significant (t= -7 .007 ,-2 .667 ,and -2 .751 ,respectively ,all P<0 .05).In addition , the serum levels of HBsAg and HBV DNA in F2 -F4 group were also significantly higher than F0 -F1 group (t= -3 .291 and -2 .831 ,respectivelt ,both P<0 .01).According to the grading of inflammation and fibrosis ,the differences of HBsAg and HBV DNA levels between F0 -F1 group and F2 -F4 group were statistically significant only in patients with more severe inflammation (t= -2 .738 and -2 .135 , respectively ,both P<0 .05) or less severe fibrosis (t= -2 .258 and -2 .333 ,respectively ,both P<0 .05).Conclusion Among CHB patients experiencing immune clearance ,serum HBsAg and HBV DNA levels are positively correlated with the severity of hepatic steatosis ,and this phenomenon is closely related to the degree of liver inflammation.

More
作者: 黄娇凤 [1] 林苏 [1] 朱月永 [1] 王明芳 [1]
期刊: 《中华传染病杂志》2018年36卷9期 528-532页 ISTICCSCD
栏目名称: 论著
DOI: 10.3760/cma.j.issn.1000-6680.2018.09.003
发布时间: 2018-12-11
基金项目:
福建省中青年教师教育科研项目(JA15207) Education and Research Projects i of Young Teachers of Fujian Province
  • 浏览:110
  • 下载:60

加载中!

相似文献

  • 中文期刊
  • 外文期刊
  • 学位论文
  • 会议论文

加载中!

加载中!

加载中!

加载中!

扩展文献

特别提示:本网站仅提供医学学术资源服务,不销售任何药品和器械,有关药品和器械的销售信息,请查阅其他网站。

  • 客服热线:4000-115-888 转3 (周一至周五:8:00至17:00)

  • |
  • 客服邮箱:yiyao@wanfangdata.com.cn

  • 违法和不良信息举报电话:4000-115-888,举报邮箱:problem@wanfangdata.com.cn,举报专区

官方微信
万方医学小程序
new翻译 充值 订阅 收藏 移动端

官方微信

万方医学小程序

使用
帮助
Alternate Text
调查问卷