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首页 > 中华创伤杂志(英文版) >Effect of leptin on bone metabolism in rat model of traumatic brain injury and femoral fracture

Effect of leptin on bone metabolism in rat model of traumatic brain injury and femoral fracture

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Objective: To observe serum and callus leptin expression within the setting of fracture and traumatic brain injury (TBI).Methods: Atotal of 64 male SD rats were randomized equally into 4 groups: nonoperated group, TBI group, fraeture group, and fracture+TBI group. Rats were sacrificed at 2, 4, 8 and 12 weeks after fracture+TBI. Serum leptin was detected using radioimmunoassay, and callus formation was measured radiologically. Callus leptin was analyzed by immunohistochemistry.Results: Serum ieptin levels in the fracture group, TBI group and combined fracture+TBI group were all significantly increased compared with control group at the 2 week time-point (P<0.05). Serum leptin in the combined fracture +TBI group was significantly higher than that in the fracture and TBI groups at 4 and 8 weeks after injury (P<0. 05).The percentage of leptin-positive cells in the fracture+TBI callus and callus volume were significantly higher than those in the fracture-only group (P<0.01).Conclusions: We demonstrated elevated leptin expression within healing bone especially in the first 8 weeks in a rat model of fracture and TBI. A close association exists between leptin levels and the degree of callus formation in fractures.

作 者 WANG Lei;YUAN Ji-shan;ZHANG Hong-xi;DING Hua;TANG Xing-guo;WEI Yong-zhong
刊 名 中华创伤杂志(英文版)  2011年14卷01期 7-13页  美国国立医学图书馆Medline数据库收录美国《化学文摘》(Chemical Abstracts)收录中国科技论文统计源期刊(中国科技核心期刊)收录
英文期刊名 CHINESE JOURNAL OF TRAUMATOLOGY
关键词 Leptin Brain injuries Fractures,bone
分类号 R6
基金项目 the Medical Science and Technology Development of Jiangsu Health Bureau(项目编号:H200512)
DOI号 10.3760/cma.j.issn.1008-1275.2011.01.002

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