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妊娠高血压综合征患者血浆P-选择素和一氧化氮含量变化及意义

Changes of plasma p-selectin and nitric oxide in patients with pregnancy induced hypertension

摘要:

目的 探讨妊娠高血压综合征(妊高征)患者血浆P-选择素和一氧化氮(nitric oxide,NO)含量的变化及其在妊高征发病中的意义。方法 采用酶联免疫吸附法测定36例妊高征患者(妊高征组,其中轻度妊高征患者11例,中重度妊高征患者25例)、18例正常晚孕妇女(正常晚孕组)和19例正常非孕妇女(正常非孕组)血浆P-选择素含量。用镀铜镉还原法测定血浆中代表NO水平的亚硝酸盐及硝酸盐(nitrite and nitrate,NO2-/NO3-)含量。结果 正常晚孕组血浆P-选择素含量为(48.92±15.16)μg/L,正常非孕组为(30.16±8.42) μg/L,两组比较,差异有极显著性(P<0.001);轻度妊高征患者血浆P-选择素含量为(47.33±17.95) μg/L,与正常晚孕组比较,差异无显著性(P>0.05);中、重度妊高征患者血浆P-选择素含量为(70.11±17.65) μg/L,与轻度妊高征患者及正常晚孕组比较,差异有极显著性(P<0.01,P<0.001);正常晚孕组血浆NO2-/NO3-含量为(63.21±14.02) μmol/L,正常非孕组为(52.17±7.20)μmol/L, 两组比较,差异有极显著性(P<0.01);妊高征组血浆NO2-/NO3-含量为(37.71±10.30) μmol/L,显著低于正常晚孕组(P<0.001);轻度妊高征患者血浆NO2-/NO3-含量为(45.52±9.03) μmol/L, 显著低于正常晚孕组(P<0.001);中、重度妊高征患者NO2-/NO3-含量低于轻度妊高征患者(P<0.05);妊高征组血浆P-选择素与NO2-/NO3-含量呈负相关。结论 妊高征患者血浆P-选择素、NO含量变化与妊高征发病及病情发展有关。

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abstracts:

Objective To study the roles of P-selectin and nitric oxide (NO) on the etiology of pregnancy induced hypertension (PIH). Methods The levels of plasma P-selectin and nitrite and nitrate (NO2-/NO3-) were determined in 36 patients with PIH. The data were compared with those of normal pregnant group (n=18) and healthy non-pregnant group (n=19). The levels of plasma P-selectin were measured by means of enzyme-linked immunosorbent assay (ELISA) and levels of plasma NO2-/NO3- were measured by Griess reaction after the nitrate was reduced by a Cadmium-reduction method. Results  The results showed: (1)The level of P-selectin in the normal pregnant group (48.92±15.16) μg/L was higher than that in non-pregnant group [(30.16±8.42) μg/L, P<0.001]. There was no significantly statistical difference in the levels of P-selectin between the normal pregnant group and the mild PIH group (P>0.05). The levels of P-selectin in the moderate and severe PIH group (70.11±17.65) μg/L were higher than those in the mild PIH group [(47.33±17.95) μg/L, P<0.01] and the normal pregnant group (P<0.001). (2)The concentration of NO2-/NO3- in normal pregnant group was higher than that in non-pregnant group (P<0.01). The concentration of NO2-/NO3- in PIH group were lower than was in normal pregnant group (P<0.001). The NO2-/NO3- in mild group was lower than that in normal pregnant group (P<0.001). The Plasma concentration of NO2-/NO3- in moderate and severe PIH group was lower than that of mild group (P<0.05). (3) There was a negative correlation between the plasma concentration of P-selectin and NO2-/NO3- in the PIH group. Conclusion The changes of plasma levels of P-selectin and NO are related to the occurrence and development of PIH.

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作者: 陈建林 [1] 林宜珍 [1] 王晨虹 [1]
期刊: 《中华妇产科杂志》2001年36卷1期 12-14页 MEDLINEISTICPKUCSCDCA
分类号: R71
栏目名称: 论著
DOI: 10.3760/j.issn:0529-567X.2001.01.003
发布时间: 2004-01-15
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