男性抗磷脂综合征临床及实验室特点的研究
The clinical and laboratory characteristics of male patients with antiphospholipid syndrome
目的 探讨男性APS的临床及实验室特点.方法 回顾性分析2003年1月至2015年4月于北京大学人民医院住院的男性APS患者33例,选择同时期住院女性APS患者114例作为对照进行分析.并且在女性患者中,选择以血栓为主要表现的68例患者再次与男性APS患者进行比较,探讨男性APS患者的血栓临床特点及实验室特征.采用x2检验或Fisher确切概率及t检验进行统计学处理.结果 33例男性患者中,原发性APS 13例(39.4%),继发性APS 20例(60.6%).与全部女性患者比较,男性患者静脉血栓的发生率明显增高(72.7%与29.8%,x2=19.719,P<0.01),多为2次及2次以上血栓(75.8%与22.8%,x2=31.669,P<0.01)和2个或2个以上部位的血栓(69.7%与22.8%,x2=25.321,P<0.01).与以血栓为主要表现的女性患者相比,差异有统计学意义.实验室指标方面,2组抗磷脂抗体的阳性率差异无统计学意义.结论 男性APS患者的血栓发生的严重程度明显高于女性,应引起临床医生的足够重视.
更多Objective To investigate the clinical and laboratory features of male patients with anti-phospholipid syndrome (APS).Methods Thirty-three male APS patients admitted to Peking University People's Hospital from January 2003 to April 2015 were enrolled.One hundred and fourteen female APS patients were selected as controls.Female patients with thrombosis were analyzed.x2 test, Fisher's exact test and t test were used for statistical analysis.Results Among male patients, 39.4% were primary APS and 60.6% were secondary APS.Compare with female patients,the prevalence of venous thrombosis was significantly higher than that in male APS (72.7% vs 29.8%,x2=19.719, P=0.000).The male APS patients experienced more episodes of thrombosis (75.8% vs 22.8%, x2=31.669, P=0.000) and not less than two locations of thrombosis than female (69.7% vs 22.8%, x2=25.321, P=0.000), there was still significant difference between male patients and female patients with thrombosis.There was no difference of antiphopholipid antibodies between the two groups.Conclusion Male patients with antiphospholipid syndrome are more prone to have thrombosis.More clinical interventions should be implemented in male patients with APS.
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