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近距离治疗是肿瘤重要的手段之一,具有局部剂量高和周围正常组织损伤小的优势.近距离治疗包括高剂量率和低剂量率两种,其中低剂量率近距离治疗是直接将放射性核素植入到肿瘤体内对肿瘤细胞进行杀伤,亦称放射性粒子组织间永久植入治疗,简称粒子植入,在早期前列腺癌治疗中取得与手术和外照射同样的疗效.3D打印技术是通过影像学图像将信息传输到计算机计划系统,以数字化设计文件为基础,通过计算机设计针道、定义处方剂量,之后3D打印机打印出个体化引导模板,引导粒子针插植和粒子植入,经头颈部、胸、腹部和盆腔初步验证,治疗精度大大提高,粒子植入治疗成为可计划、可优化和可评估的标准技术手段,开启放射性粒子组织间植入治疗全新时代.

Brachytherapy is an important modality for cancer treatment,with advantages of local high doses and little damages to surrounding normal tissues,including high and low dose rate.In the low dose rate brachytherapy,the seeds are implanted into the locations of tumor by way of puncture to kill the tumor cells.The low dose rate brachytherapy for prostate cancer has received the same outcome with surgery and external radiation therapy.3D-printing template was produced by computer program based on image scan information and the needle tract,based on definition of the target prescription dose and 3D-printing template assisted CT guidance for needles puncture and seed implantation.Seed implantation has become the standard procedure in treatment for head and neck,thoracic,abdomen and pelvic cancers according to pre-plan,real-time optimization and post-dese evaluation,which is a symbol of new era for seed implantation.