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宫颈癌IMRT计划独立三维剂量验算的初步应用与探讨

Preliminary application and discussion of independent 3D dose calculation in intensity-modulated radiotherapy for cervical cancer

摘要:

目的 评估自动计划验证系统Mobius3D (M3D)在宫颈癌IMRT中进行独立三维剂量验算的可行性.方法 随机选取20例宫颈癌病例,将其分别在Pinnacle 9.2和Eclipse 13.5计划系统中进行7个野均分IMRT计划设计,达到临床要求后将两套计划系统中优化计划分别导入M3D中.观察两套TPS在传输计划过程中ROI体积变化、靶区及OAR剂量计算差异,结合γ通过率评估M3D验算计划的精确性.结果 Pinnacle9.2传输至M3D中各ROI体积差异远远小于Eclipse 13.5,其最大变化差异为0.22%±0.69%,Eclipse13.5中最大变化差异为3.50%±1.89%.M3D中显示两套TPS的靶区及OAR剂量计算值差异在±1%内,经过3D重新计算后Pinnacle9.2与M3D计算结果差异小于Eclipse 13.5,但其平均差异均在±3%内.靶区和OAR的γ通过率均值>95%.结论 利用自动计划验证系统进行计划验证,过程方便快捷.目前可作为计划的二次检查应用,提高IMRT计划验算精确性.

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Objective To assess the feasibility for the automated treatment planning verification system Mobius3D (M3D) to perform an independent 3D dose calculation in intensity-modulated radiotherapy (IMRT) for cervical cancer.Methods Twenty patients with cervical cancer were randomly selected.With treatment planning systems (Pinnacle,Version 9.2;Eclipse,Version 13.5),all IMRT plans were divided into 7 fields to meet the dosimetric goals.The optimized plans were exported to the M3D server.The percentage differences in the volume of region of interest (ROI) and the dose calculation of target volume and organ at risk (OAR) were evaluated for the two treatment planning systems,and theγ passing rate was used to assess the accuracy of M3D calculation.Results The difference in the volume of ROI for Pinnacle 9.2 to M3D was less than that for Eclipse 13.5 to M3D,with maximum differences of 0.22%±0.69% and 3.5%±1.89% for Pinnacle 9.2 and Eclipse 13.5,respectively.The differences in the dose calculation of target volume and OAR for the two treatment planning systems to M3D were within ± 1%.After recalculating by M3D,the dose difference between Pinnacle 9.2 and M3D was smaller than that between Eclipse 13.5 and M3D,but the mean differences were all within ±3%.The γ passing rates for target volume and OAR were more than 95% on average.Conclusions The method of utilizing the automated treatment planning verification system to validate the accuracy of plans is convenient.It can be used as a secondary check tool to improve accuracy in IMRT dose calculation.

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作者: 刘潇 [1] 尹勇 [1] 王莉 [2] 卢洁 [1] 陈进琥 [1]
期刊: 《中华放射肿瘤学杂志》2017年26卷4期 433-436页 ISTICPKUCSCD
栏目名称: 物理·生物·技术
DOI: 10.3760/cma.j.issn.1004-4221.2017.04.014
发布时间: 2017-04-26
基金项目:
山东省科技攻关项目 国家自然科学基金(81472811、81272699)Science and Technology Project of Shandong Province National Natural Science Foundation of China
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