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肝硬化门静脉高压症的发生发展与肝内血流阻力增加以及全身高动力循环有关.这两种病理改变均与肝内或全身循环舒血管物质异常减少或增加有关.活性氧导致的血管低反应性也是肝硬化门静脉高压症患者全身高动力循环形成的因素之一.核因子E2相关因子2(Nrf2)是人们熟知的体内抗氧化相关因子.Nrf2不但可在机体受到氧化应激时激活抗氧化反应元件(ARE)基因的转录与表达,同时也可影响机体重要舒血管物质一氧化氮、一氧化碳和他们合成酶的表达.探究其在肝硬化门静脉高压症中的表达变化及调控方式,具有潜在的临床应用价值.

Cirrhotic portal hypertension is associated with both increased intrahepatic vascular resistance and hyperdynamic circulation.These two pathogical changes of portal hypertension can be contributed to the unusually high or unusually low levels of vasodilator in liver and splanchnic organs.Vascular hyporesponsiveness due to reactive oxygen species is also a key factor which accounts for portal hemodynamic abnormalities.Transcription factor nuclear factor E2-related factor 2 (Nrf2),known by its role in anti-oxygenation,can initiate and enhance transcription of antioxidant response element (ARE) when exposure to oxidative stress occures.Related influence on expression of nitric oxide,carbon monoxide and their coenzymes has also been demonstrated for decades.The potential clinical significance will be unfolded if changes of Nrf2 expression,as well as the way modulating Nrf2,are found in cirrhotic portal hypertension.