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目的 探讨远航对潜艇官兵神经内分泌和免疫系统的影响.方法 选取潜艇官兵55名做为研究对象,采用酶联免疫吸附法(ELISA)检测55名官兵的血清肌酸激酶(CK)、三酰甘油(TG)、葡萄糖(GLU)和尿酸(UA)水平,并利用试剂盒检测其中36名官兵血清去甲肾上腺素(NE)、皮质醇(COR)、热休克蛋白70(HSP70)、白细胞介素也(IL-2)和白细胞介素4(IL-4)水平.结果 (1)远航后NE[(313.68±146.51) ng/L]较远航前[(224.80±118.52) ng/L]升高,差异有统计学意义(P＜0.01);远航后COR[(18.40 ±6.91)μg/L]较远航前[(14.73 ±8.70) μg/L]略有升高(P=0.075);HSP70远航后[(149.02 ±72.22) μg/L]较远航前[(109.02 ±59.92) μg/L]升高,差异有统计学意义(P＜0.05).(2)远航后GLU[(4.27 ±0.67) mmol/L]较远航前[(4.60 ±0.56) mmol/L]降低,差异有统计学意义(P＜0.05);CK、TG和UA远航后[(217.76±181.21)U/L、(2.05 ±0.91) mmol/L、(407.11±60.81) μmol/L]均较远航前[(119.67 ±75.88) U/L、(1.32±0.55) mmol/L、330.18 ±70.93) μmol/L]升高,差异有统计学意义(P＜0.01).(3)远航后IL-2、IL-4[(424.44±166.04) ng/L、(361.13±163.47) ng/L]均较远航前[(331.95±173.11)ng/L、(246.42±166.20) ng/L]升高,差异有统计学意义(P＜0.05).结论 远航对潜艇官兵的免疫系统产生了一定的激活作用,并可引起神经内分泌生化指标的改变.

Objective To investigate the effects of prolonged deployment at sea on the neuronendocrine-immune system of submariners.Methods Fifty-five submariners were screened for the study.The levels of creatine kinase (CK),trigeminal ganglion (TG),glucose (GLU) and uric acid (UA) were detected with ELISA,and levels of serum norepinephrine (NE),corticosteroid (COR),heat shock protein (HSP70),interleukin 2 (IL-2) and IL-4 were also detected with testing kits in 36 research subjects.Results (1) The level of NE [(313.68 ±146.51)ng/L] measured after prolonged deployment was significantly higher than that measured before deployment [(224.80 ± 118.52) ng/L] (P ＜ 0.01),the level of COR[(18.40 ± 6.91) μg/L] after prolonged deployment elevated slightly than that before deployment [(14.73 ± 8.70) μg/L] (P =0.075),and the level of HSP70 [(149.02 ± 72.22) μg/L] after the prolonged deployment elevated considerably,as compared with that before deployment [(109.02 ± 59.92) μg/L] (P ＜ 0.05).(2) The level of GLU [(4.27 ± 0.67)mmol/L] measured after prolonged deployment decreased considerably,as compared with that of predeployment [(4.60 ± 0.56)mmol/L] (P ＜ 0.05),the levels of C K,TG and UA [(217.76 ± 181.21)U/L,(2.05 ± 0.91)mmol/L and(407.11 ± 60.81)μmol/L] after the prolonged deployment elevated significantly,as compared with those [(119.67 ± 75.88) U/L,(1.32 ± 0.55) mmol/L and (330.18 ± 70.93) μmol/L] before deployment (P ＜ 0.01).(3) The levels of IL-2 and IL-4 [(424.44 ± 166.04) ng/L,(361.13 ± 163.47)ng/L]measured after deployment were significantly higher than those [(331.95 ±173.11)ng/L and (246.42 ± 166.20) ng/L] before deployment (P ＜ 0.05).Conclusions Prolonged deployment at sea could activate the immune system of submariners to a certain extent and might induce changes in neuroendocrinology.