18F-FDG PET在恶性肿瘤上皮间质转化理论研究与临床应用中的进展
Recent advance in the theoretical research and clinical application of 18F-FDG PET in assessment of epithelial-mesenchymal transition
上皮间质转化(EMT)是肿瘤多种恶性生物学行为共同的分子驱动因素.在体检测EMT对早期预测肿瘤转移和治疗抵抗,监测靶向EMT逆转化疗耐药有重要作用,但目前探测EMT的方法主要依赖于对肿瘤组织或细胞的分子标志物检测.以糖代谢为基础的18F-脱氧葡萄糖(FDG)PET显像有潜力成为无创性诊断和监测EMT的影像学手段,该文综述了18F-FDG PET评价EMT的相关理论研究及临床应用进展.
更多Epithelial-mesenchymal transition (EMT) is recognized as a central driver for many malignant tumor behaviors.Detection of EMT plays the pivotal role in early prediction of tumor metastasis and therapy resistance,as well as in evaluation of targeting EMT to reverse chemoresistance.Nowadays,the major way to distinguish EMT mainly depends on examination of molecular biomarkers of acquired tumor tissues or cells.18F-fluorodeoxyglucose (FDG) PET imaging,which reflects the glucose metabolism,has emerged as a potential method to diagnose and govern EMT.This review summarizes the recent advances in theoretical research and clinical application of 18F-FDG PET in assessment of EMT.
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