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目的 探讨反映动脉僵硬度的参数压力反射波增强指数(AI),与高血压患者肾脏功能水平变化之间的关系.方法 通过健康体检及社区调查入选高血压患者478例,检测入选患者的动脉弹性参数及血清肌酐水平,计算人选患者肾小球滤过率(eGFR),按不同节点分为三组,分析AJ与肾功能状态之间的相关关系,并建立回归方程.结果 高血压患者eGFR三组的AI不同肾功能水平,差异有统计学意义(80.47±16.22,91.23±11.36,95.77±12.13)(P＜0.01).eGFR降低同时将伴有AJ水平的增加(β=-0.258,t=-5.843,P＜0.0001),而AI水平的增加同样伴有估测eGFR的降低(β=-0.219,t=-4.793,P＜0.0001).在引入年龄,血压等多因素后这种关系仍然成立(β=-0.188,t=-3.331,P＜0.05).结论 随着高血压患者AI水平的逐渐增高,动脉僵硬度的逐渐减退,肾脏功能有逐渐下降的趋势,因此,AJ对于高血压患者的肾功能水平的变化具有良好的预测性.

Objective To evaluate the relationship between renal function and augmentation index (AI) in hypertension. Methods 478 patients were enrolled through health examination and all the patients received AI measurement, glomerular filtration rate ( eGFR) was estimate by serum creatinine. Regression equation was bulilt based on correlation analysis results. Results Patients'augmentation index varied with renal function(80. 47 ± 16. 22 vs 91. 23 ± 11. 36 vs 95. 77 ± 12. 13 ,P <0.01) AI correlated significantly and negatively with eGFR, decreased eGFR came with increased AI level ( β = - 0. 258, t = - 5. 843, P < 0.0001),and with the increase of AI, eGFR will decreased (β= -0.219,?= -4.793,P<0. 0001). A multiple regression analysis revealed that AI correlated independently with eGFR(β = -0. 188 ,t = -3. 331, P < 0. 05). Conclusions There was a stepwise increase in AI, corresponding to advances of the renal damage,the newly proposed eGFR is significantly associated with arterial stiffness,AI had good predictability for renal function in hypertensive patients.