检索历史 清除

目的 探讨代谢综合征(MS)不同组分、聚集数目及聚集方式与女性亚临床期颈动脉粥样硬化的关系,为心脑血管疾病防治提供更多信息.方法 整群抽取3个事业单位女性体检人群835例,按照ATPⅢ标准定义MS.按年龄分组为25岁～、45岁～、65岁～;根据MS五个组分的聚集数目分为0、1、2、3、4、5组;再按照MS组分不同聚集方式分为16组;对上述各组人群行颈动脉超声检查,以颈动脉中内膜增厚和粥样斑块形成作为亚临床期颈动脉粥样硬化评价指标,比较MS各组分,各组分不同的聚集数目及不同的聚集方式对亚临床期颈动脉粥样硬化的影响.结果 MS总患病率27.8%,五个组分异常率分别为中心性肥胖69.3%,高血压31.0%,高密度脂蛋白胆固醇减低31.0%,高三酰甘油血症21.4%,高血糖18.1%.结果 显示,中心性肥胖、高血压、低高密度脂蛋白胆固醇致颈动脉粥样硬化风险最强.随着组分聚集数目增加,颈动脉粥样硬化检出率不同程度增加,与0个组分相比,分别具有1、2、3、4、5个组分者患动脉粥样硬化的风险分别是0个组分的1.4倍、2.0倍、3.4倍、5.7倍及7.1倍;MS各组分不同的聚集方式对颈动脉粥样硬化产生不同的影响,常见的聚集方式为含有中心性肥胖组分与其他各组分的聚集.结论 MS每一组分均是亚临床期颈动脉粥样硬化的独立危险因素;随着组分聚集数目增加颈动脉粥样硬化患病风险成算术级别增加;MS各组分不同的聚集方式对颈动脉粥样硬化产生显著影响.

Objective To investigate the relationship between metabolic syndrome (MS) and female subclinical carotid atherosclerosis. Methods A total of 835 female subjects were enrolled in this study. MS was defined based on the ATP Ⅲ criteria. Age groups were ＜45,45 to 65,and ≥65 years. The participants were evaluated by the number of components of MS and clusters of MS components. Measurement of carotid arteries with B-mode ultrasound imaging was performed. Intima-media thickness and plague of the carotid arteries were regarded as the indicators of subclinical carotid atherosclerosis. Results The prevalence of carotid atherosclerosis, MS components and MS was significantly increased with the increased age. After age was adjusted, multiple logistic regression analysis showed that every component of MS was independently associated with carotid atherosclerosis; the increased waist circumstance and blood pressure and reduced HLD showed stronger effect. The prevalence of carotid atherosclerosis was increased with increasing number of components of MS. When compared to the 0 MS component group,the odds ratio (OR)of carotid atherosclerosis of the groups with 1, 2,3,4, or 5 components were 1.4,2. 0,3.4,5. 7 and 7. 1,respectively. The altered cluster components of MS impacted differently on carotid atherosclerosis. The clusters of components of MS with increased waist circumstance were more frequent than without ones. Conclusion Every component of MS may be an independent risk factor of carotid atherosclerosis;increased components of MS could contribute higher odd risk to carotid atherosclerosis; clusters of MS components might show different impacts on carotid atherosclerosis.