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目的 研究我国成年人饮酒状况对代谢综合征(MS)发病的影响.方法 本项目为前瞻性队列研究.2007至2008年对分别于1998和2000年基线调查的中国心血管病流行病学多中心协作研究35 ～ 74岁的27020例队列人群开展随访调查.结果 基线14572例非MS人群经8年随访,共发生MS 2362例.在调整了年龄、南北方、城乡、受教育程度、体力活动、吸烟、体质指数以及MS组分数后,和不饮酒者相比,男性饮酒者发生MS的相对危险度(RR)为1.24(95％ CI:1.06～1.45),人群归因危险度为10.13％；每日摄入酒精量10.1～20 g,20.1～40 g,＞40 g组的RR分别为1.36(95％CI:1.02～ 1.82),1.34(95％ CI:1.03～ 1.74)和1.41 (95％CI:1.13,～1.77)；每周饮酒2～5次和≥6次的RR分别为1.25(95％CI:1.01～ 1.55)和1.26(95％CI:1.04～ 1.52)；只喝啤酒组、只喝白酒组和混合饮酒组的RR分别为1.60(95％ CI:1.05～2.45)、1.30(95％CI:1.02～ 1.65)和1.27(95％CI:1.06 ～ 1.52).女性每日摄人酒精量在10.1 ～20 g组和＞20g组RR分别为2.67(95％CI:1.26～5.65)和2.38(95％CI:1.35～4.22).结论 在全人群中,每日摄入酒精量＞10 g就会显著增加MS发病风险,在女性中尤为明显.男性每周饮酒≥2次以及只饮啤酒、只饮白酒和混合饮酒者均明显升高MS的发病风险.为减少MS的流行,应提倡限制酒精过量摄入,尤其女性更应限制酒精摄入量(≤10 g/d).

Objective To examine the relationship between alcohol consumption and the incidence of metabolic syndrome (MS) in Chinese adults.Methods A total of 27020 Chinese adults aged 35 to 74years were enrolled in this prospective cohort study.Frequency or type of alcohol consunption was assessed in 1998 and 2000.Follow-up study on MS was conducted during 2007 and 2008.Results Over an average 8years' follow-up,2362 MS patients were identified among 14 572 individuals who did not have MS at baseline.After adjustment for age,location,education level,physical activity,cigarette smoking,body mass index and the number of MS components,compared with non-drinkers,relative risk ( RR ( 95％ confidence interval (CI))) and the Population Attributable Risk Percent (PARP) of MS of male drinkers was 1.24( 1.06 to 1.45 ) and 10.13％,respectively.RR (95 ％ CI) of MS was 1.36 ( 1.02 to 1.82 ),1.34 ( 1.03 to 1.74) and 1.41 (1.13 to 1.77) for male drinkers consuming alcohol 10.1 -20 g/d,20.1 -40 g/d,and ＞40 g/d.RR(95％ CI) of MS was 1.25 ( 1.01 to 1.55) for males drinking 2 -5 times/week and 1.26(1.04 to 1.52) for males drinking ≥6 times/week.RR (95％ CI) of MS was 1.60 ( 1.05 to 2.45),1.30(1.02 to 1.65) and 1.27 (1.06 to 1.52) for beer,liquor and the beer + liquor male consumers.The corresponding RR(95％ CI) was 2.67(1.26 to 5.65) and 3.38 (1.35 to 4.22) for female drinkers consuming alcohol 10.1 -20 g/d and ＞20 g/d.Conclusions Drinking alcohol more than 10 g/d may be associated with an increasing risk of MS,especially for women.Drinking more than twice per week,beer and/or liquor consumption can significantly increase the risk of MS in men.