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正常体质指数性肥胖与心血管危险因素的研究

Relationship between normal weight obesity and cardiovascular risk factors

摘要:

目的 探讨体质指数(BMI)正常但体脂肪含量(BF%)偏高的正常体质指数性肥胖(NWO)与心血管危险因素之间的关系.方法 采用横断面研究的方法对健康体检者940名,选取BMI介于18.5 ~25 kg/m2者407名.利用生物电阻抗( BIA)原理进行BF%测定,按BF%≥25%(男)或BF% >35%(女)定义为NWO组,BF%< 25%(男)或BF%< 35%(女)者为对照组.两组心血管危险因素水平及检出率的比较采用独立样本t检验和x2检验.Logistic回归分析NWO组发生各心血管危险因素的危险度(OR).结果 男性、女性NWO检出率分别为13.13%、14.91%.随年龄增长NWO检出率有增高趋势(趋势x2=6.90,P<0.05).NWO组收缩压、舒张压、总胆固醇、三酰甘油、低密度脂蛋白胆固醇及尿酸水平均高于对照组(t分别为2.97、2.44、2.54、5.09、2.71和3.91,P<0.05),高密度脂蛋白胆固醇水平低于对照组(t=-3.90,P<0.05).高血压、高血糖、高三酰甘油、低高密度脂蛋白胆固醇、血脂异常及高尿酸的检出率NWO组均高于对照组(x2分别为6.76、5.58、14.50、11.97、10.97和8.76,P<0.05).NWO组高血压、高血糖、高血脂和高尿酸的发病风险分别是对照组的2.186、2.120、2.088和4.175倍.校正了年龄和性别因素,NWO组高尿酸的发病风险降低为对照组的3.491倍.结论 NWO与心血管危险因素相关,是具有高心血管疾病危险的群体.

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abstracts:

Objective To determine the relationship between normal weight obesity (NOW) and cardiovascular risk factors.Methods A total of 940 adults who received a health examination in out hospital were recruited in a cross-sectional study,and 407 with a body mass index (BMI) of18.5 to 25 kg/m2 were enrolled for further analysis.Body fat percentage ( BF% ) was measured by bioelectrical impedance analysis (BIA),and the subjects were assigned to the NOW group ( BF% ≥25% for male or BF% ≥35%for female) or the control group ( BF% < 25% for male or BF% < 35% for female).Cardiovascular risk factors and their detection rates were compared between the two groups by using independent sample t test and x2 test.The correlation between NOW and cardiovascular risk factors was assessed by logistic regression.Results The prevalence of NOW in men and women were13.1% and14.9%,respectively.The prevalence of NOW was increased with age ( x2 =6.90,P <0.05 ).Systolic blood pressure (SBP),diastolic blood pressure ( DBP ),total cholesterol ( TC ),triglycerides ( TG ),low-density lipoprotein cholesterol ( LDL-C) and serum uric acid (SUA) were significantly increased in the NOW group (t values were 2.97,2.44,2.54,5.09,2.71and 3.91,respectively; all P < 0.05 ) ; whereas high-density lipoprotein cholesterol ( HDL-C) was significantly decreased in the NOW group (t =-3.90,P < 0.05 ).The prevalence of hypertension,hyperglycemia,high triglyceride,low HDL-C,dyslipidmia and hyperuricemia was increased in the NOW group in comparison with the control group ( x2 values were 6.76,5.58,14.50,11.97,10.97 and 8.76,respectively; all P< 0.05 ).Logistic regression showed NOW increased the risk of hypertension,hyperglycemia,dyslipidmia or hyperuricemia by 2.186,2.120,2.088 or 4.175 times.After adjustment for age and gender,the risk for hyperuricemia was decreased to 3.491,but remained statistically significant higher.Conclusions NOW may be correlated with cardiovascular risk factors,and those with NOW could be at higher risk for cardiovascular diseases.

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作者: 赵辉 [1] 冷松 [1] 刘颖 [1] 孙广慧 [1] 于书君 [1]
期刊: 《中华健康管理学杂志》2012年06卷4期 255-258页 ISTICCSCD
分类号: R544.1
栏目名称: 论著
DOI: 10.3760/cma.j.issn.1674-0815.2012.04.011
发布时间: 2012-11-16
基金项目:
大连市科学技术基金计划项目
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