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目的 观察综合干预在抗精神病药物所致便秘患者中的效果.方法 将2012年6月至2013年10月在我院就诊的90例抗精神病药物所致便秘患者分为综合干预组46例和常规治疗组44例.常规治疗组进行常规药物、饮食治疗,综合干预组实施从生活、心理、认知、护理等多方面综合干预,为期3个月.在干预前后采用便秘症状尺度表和便秘状况评估问卷(PAC-QOL)对患者进行评估.结果 综合干预组排便困难、过度用力排便、排便所用时间、频率积分、腹胀积分、症候总积分分别为(2.8±2.1)、(2.2±1.6)、(2.4±1.3)、(2.1±1.7)、(1.5±0.9)、(14.0±8.1)分;改善均优于常规治疗组(t=2.629、3.818、2.328、2.593、2.578、2.913,P＜0.05).综合干预组PAC-QOL总积分、躯体不适、心理社会不适、担心和焦虑、满意度优于常规治疗组(t=7.499、2.570、5.012、2.249、12.259,P＜0.05).结论 对抗精神病药物所致便秘患者实施综合干预治疗,可作为促进患者康复的有效措施.

Objective To explore the effect of comprehensive intervention on constipation caused by antipsychotic drugs.Methods Ninty patients with antipsychotic drug induced constipation who were admitted to our hospital from June 2012 to October 2013 were enrolled in this investigation and randomly assigned to the comprehensive intervention group(CIG,n=46) and the routine care group(RCG,n=44).The subjects of the RCG received routine diet and medication therapy; and those of CIG received comprehensive intervention of life style,psychological ability,cognition,nursing and traditional chinese medicine(TCM) for 3 months.Constipation symptoms scale and Patient Assessment of Constipation Quality of Life Questionnaire (PAC-QOL) were assessed before and after the intervention.Results CIG showed significant improvement in defecation difficulty,defecation force,defecation duration,frequency,abdominal distension,total symptom score,PAC-QOL,physical discomfort,psycho-social discomfort,anxiety and treatment satisfaction were(2.8±2.1),(2.2±1.6),(2.4±1.3),(2.1±1.7),(1.5±0.9),(14.0±8.1)respectively (t values were 2.629,3.818,2.328,2.593,2.578,2.913,7.499,2.570,5.012,2.249 and 12.259,respectively; all P＜0.05).Conclusion Comprehensive intervention may be an effective therapy against psychiatric drug induced constipation.