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目的：分析中年健康体检人群体质指数（BMI）、血压与脑血管功能变化的关系。方法以现况研究设计，整群抽取湖北省人民医院、湖南南华大学附属第二医院、山东电力医院、解放军180医院健康管理中心健康体检者中45～64岁中年人群，测量身高、体重、血压，并进行脑血流动力学检测，按年龄、BMI、收缩压和舒张压水平依次进行分组，比较不同组别脑血流动力学积分值的差异，描述其分布特征，进而评估卒中风险。结果符合纳入标准的研究对象总共17258人，脑血管功能积分值的异常率（<75分）占20.9%。按BMI值分组，正常体重、超重和肥胖组的脑血管功能积分值（分）分别为91.0±15.4、83.3±21.3、70.3±26.5，且各年龄层不同BMI的组间差异均有统计学意义（P<0.01）。收缩压<120、120~139、140~159、≥160 mmHg（1 mmHg=0.133 kPa）的体检者，其脑血管功能积分值（分）分别为93.9±12.9、86.5±18.9、72.1±23.5、56.2±25.7，且各年龄层不同血压水平组间的差异均有统计学意义（P<0.01）。舒张压<80、80~89、90~99、≥100 mmHg的体检者，其脑血管功能积分值（分）分别为91.0±16.1、85.5±20.2、75.4±23.6、62.7±25.0，且各年龄层不同血压水平组间的差异均有统计学意义（P<0.01）。上述分组间脑血管功能积分值的异常率也呈现相应的变化规律，组间差异均有统计学意义（P<0.01）。结论中年体检人群脑血管功能异常、卒中风险增高者的比例约占21%，超重、肥胖和收缩压、舒张压水平升高均对脑血管功能造成损害，损害程度随着BMI和血压水平升高而加重。

Objective To analyze the relationships between body mass index (BMI), blood pressure and the cerebral vascular function in middle-aged population that underwent health checkup. Methods Participants from health management centers of Renmin Hospital of Hubei province, the Second Hospital Affiliated to Nanhua University, Hospital of Shandong Electric Power and Chinese People's Liberation Army No. 180 Hospital aged 45 to 64 years were selected from health checkup population by cluster sampling. Levels of height, weight and blood pressure as well as the cerebral hemodynamics were checked. Subjects were grouped according to age, BMI, systolic and diastolic blood pressure. The differences and distribution of cerebrovascular function scores (CVFS) between groups were compared and described. Moreover, the risk of stroke in the population was evaluated. Results Of the 17 258 individuals who met inclusion criteria, the abnormal rate (the score below 75 points) of CVFS was 20.9 percent. The CVFS in normal, overweight and obese groups were 91.0±15.4, 83.3±21.3, 70.3±26.5 and differences in all age groups were statistically significant (P<0.01). The CVFS in systolic blood pressure<120,120-139, 140-159,≥160 mmHg (1 mmHg=0.133 kPa) groups were 93.9±12.9, 86.5±18.9, 72.1±23.5, 56.2±25.7 and differences in all age groups were statistically significant (P<0.01). CVFS in normal diastolic pressure<80, 80-89, 90-99,≥100 mmHg groups were 91.0±16.1, 85.5±20.2, 75.4±23.6, 62.7±25.0 and the differences among all age groups were statistically significant (P<0.01). Conclusions The abnormal rate of cerebrovascular function integral and high risk stroke individuals in middle-aged health checkup people was approximately 21 percent. The overweight, obese and the high level of systolic and diastolic pressure may induce the injury of cerebrovascular function and the severity will increase with the level of BMI and blood pressure.