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严重肝病的病因非常复杂,在我国以乙型肝炎和丙型肝炎最为常见,但近年酒精性肝病、自身免疫性肝病等非病毒性严重肝病有上升趋势.严重酒精性肝病治疗迄今仍无特效药物,主要病因治疗是肾上腺皮质激素(GC)和己酮可可碱.对于自身免疫性肝病,目前仍采用免疫抑制剂和GC治疗,生物制剂干扰信号转导途径的研究有望成自身免疫性肝病新的治疗途径.Wilson病的治疗采用错时给药或交替联合给药,可避免不良反应的叠加;而细胞移植治疗和基因治疗将是未来研究的方向.总之,严重肝病治疗时应结合具体情况,采取有效治疗措施,争取提高患者的存活率.

Severe liver diseases have various etiology.Hepatitis B and hepatitis C are commonly seen in China.However,alcoholic liver disease, autoimmune liver disease (ALD) and other non-viral severe liver diseases have shown an upward trend in recent years.There are no special therapeutical methods for severe alcoholic liver disease so far, glucocorticoids and pentoxifylline are mainly used for etiological treatment.The autoimmune liver disease is still one of the remarkable problems in the filed of liver diseases;at present, immunosuppressive agents and corticosteroids are routinely used for this liver disease, study on transduction pathway of biological agents interfering signals is expected to be a new therapy for ALD.The Wilson's disease is treated by administrating in a staggered manner or alternate manner to avoid the overlap of adverse reactions, while cell transplantation therapy and gene therapy will be the direction of future research.In conclusion, effective therapy should be given with reference to detailed condition, so as to improve survival rate in patients with severe liver diseases.