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目的 分析垂体瘤卒中的流行特征,并探讨卒中所致的内分泌激素变化及特点.方法 回顾性分析垂体瘤和垂体瘤卒中的临床、实验室、激素水平及内分泌功能检测、影像、术中及病理所见 结果 (1)垂体瘤卒中发生率31.78％,年龄15 ～75(47.5± 11.7)岁,女多于男；(2)伴糖尿病、冠心病、人工月经疗法、放疗、手术、溴隐亭可能与诱发卒中有关；(3)本资料无功能垂体瘤发生卒中率高；(4)本资料从卒中与垂体瘤间关系分为5型:卒中起病型、卒中加重型、卒中潜在型、卒中意外型和卒中术后型；(5)垂体瘤卒中易伴发低肌酐血症,高钠、氯血症,血嗜酸、嗜碱细胞减少症；(6)伴垂体激素缺乏高达61.61％,表现为单激素或多激素缺乏,其中GnH缺乏发生率最高；(7)98.10％采用手术治疗.结论 垂体瘤卒中有特点的临床特征,应引起临床重视.

Objective To analyze the epidemiological characteristics of pituitary apoplexy and investigate the changes and features of endocrine hormones caused by pituitary apoplexy.Methods A retrospective analysis of the clinical and laboratory data of pituitary tumor and pituitary apoplexy was carried out.Results (1) The incidence of pituitary apoplexy was 31.78％,patients were 15-75 (47.5 ± 11.7) year old,most patients were female.(2)Diabetes,coronary heart disease,menopausal hormone therapy,radiotherapy,surgery,and bromocriptine administration may be related to pituitary apoplexy.(3) There was high incidence of apoplexy in nonfunctioning adenoma.(4) According to the relationship between apoplexy and pituitary tumor,cases with pituitary apoplexy were divided into 5 types.(5) Pituitary apoplexy was associated with low serum creatinine,hypernatremia,hyperchloremia,hypoeosinophilia,and hypobasophilia.(6) 61.61％ of the patients had pituitary hormone deficiency,especially the GnH deficiency.(7)98.10％ of the patients were treated by surgery.Conclusion Pituitary apoplexy has its own clinical characteristics,and more attention should be paid in clinical practice.