未发育成熟缺损颅骨后期生长的形态学研究
Morphological study of growth of immature deflected skull
目的 探讨未发育成熟缺损颅骨后期生长的形态学变化.方法 20只2月龄小尾寒羊(雌雄各半)采用随机数字表法分为2组,手术组、对照组各10只.将手术组幼羊颅骨顶部手术去除造成直径4 cm的颅骨缺损,观察后期颅骨及缺损边缘的骨生长情况,并与对照组(不做任何处理,与手术组在相同环境下饲养)比较各项指标.结果 手术组2只分别死于并发症及外伤,2只出现颅骨缺损区下方脑组织萎缩,并伴有神经精神症状.骨窗边缘有新生骨向心性生长,所有缺损区面积均变小.但新生骨骨质薄弱.另有1只骨窗边缘新生骨有部分呈外翻性畸形生长.其余指标与对照组对比无显著性差异.结论 幼羊颅骨缺损后未出现颅骨发育畸形,其骨窗可因新生骨生长而变小,缺损未完全愈合,也不足以达到正常强度,不能有效起到对脑组织的保护作用.
更多Obiective To study the morphological changes of immature defected skull in later growth. Methods Twenty 2-month small-tail Han sheep (female/male ratio 1:1) were randomly divided into operation group(n=10)and control group(n=10).In the former,the parietal skull of 4 cm in diameter was removed in each sheep so as to observe the growth condition of defected bone.In the latter,the sheep were kept in the same envimnmem as the operation group,but without any operation.Results In the operation group, 2 sheep died from complications and trauma, 2 suffered from cerebral atrophy right under defected area,accompanied with psychiatric symptom,and 1 developed everted growth on the margin of bone window;in the others,the margin of bone window appeared afferent growth,which made the defected area smaller, but the new bone was thin and weak relatively. The rest indexes were not different between the 2 groups. Conclusions Skull defect won't lead to skull development malfomlation, and it can be repaired to some extent by bone growth, but the growth can not close completely the defect and make it strong enough for protecting the brain tissue.
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