慢性缺血性脑卒中患者全脑功能网络小世界属性改变
Small-world properties of the brain functional networks in patients with chronic ischemic stroke
目的:利用静息态功能磁共振( fMRI)探讨慢性缺血性脑卒中患者全脑功能网络小世界属性的特点。方法对2013年6月至2014年6月东南大学附属中大医院神经内科门诊42例慢性缺血性脑卒中患者及25例匹配的健康对照分别进行静息态fMRI扫描,构建全脑功能网络;比较两组受试者小世界属性并探讨其变化,相关参数包括:全局效率Eglobal ,局部效率Elocal ,最短路径长度Lp,聚类系数Cp,γ,λ,σ。结果在0.1≤稀疏度≤0.2范围内,两组均符合小世界属性(σ>1)。脑卒中组所在阈值点Cp及Elocal明显低于健康对照组,差异有统计学意义( P<0.05)。结论两组受试者的全脑功能网络虽仍具有小世界属性,但卒中患者拓扑属性已经发生改变,网络小世界性低于健康对照组,Cp及Elocal值降低,这些改变能为疾病的病理生理机制提供新视角,对于加深该类疾病的认识具有重要意义。
更多Objective To explore the characteristics of small-world properties of the brain functional networks in patients with chronic ischemic stroke.Methods A total of 42 stroke patients and 25 matched healthy volunteers were scanned with BOLD-fMRI and the whole-brain functional networks were constructed.Two sample t-tests were used to evaluate the changes.The properties including Eglobal , Elocal , Lp, Cp,γ,λ,σ.Results Within 0.1≤sparsity≤0.2, both groups satisfied the small-world properties (σ>1). However,the Cp and Elocal of stroke group was significantly lower ( P<0.05).Conclusions The networks in both groups still satisfied the small-world but parts of the properties in patients have changed.The reduced properties including Cp and Elocal .These changes will provide a new perspective for pathophysiological mechanism and also be helpful for understanding this disease.
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