个体化医学的现状、挑战与对策
Personalized medicine:current status, challenges and strategies
现代药物基因组学研究证明,人类遗传和基因多态性是药物不良反应及其疗效个体差异的首要原因.个体化医学则是根据个体的遗传结构,选择适合患者的药物种类和剂量,以显著提高药物疗效并减少药物毒性.本文介绍国内外药物基因组学进展,评述个体化医学由科研推向临床应用的各种影响因素,阐明个体化医学实施面临的挑战,展望个体化医学的未来.
更多Modern pharmacogenomics demonstrates that genetic polymorphisms account for the most important factor of adverse drug reactions and interindividual variations of drug therapy. Personalized medicine aims to choose the appropriate drugs and dosage for increasing the efficacy and safety with minimal adverse effects based on the patients' genotypes. This article introduce the progresses in pharmacogenomics in China, discusse many factors that influence the application of personalized medicine from bench to bedside, and highlighted the challenges and further development of this field in the future.
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