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细胞外囊泡(EVs)是细胞释放的微小囊泡,其中包含蛋白质、核酸等生物标志物.EVs生物标志物可灵敏反映疾病发生发展情况,与组织活检相比,其检测具有无创、取样简便、可实时监测等优势,故EVs生物标志物的研究与临床应用已成为国际研究热点.本文对EVs生物标志物研究现状与筛选策略进行梳理总结,鼓励加快EVs生物标志物的筛选与检测技术的研发以及EVs生物标志物研究成果向疾病临床诊疗应用的转化.

Extracellular vesicles ( EVs ) are small vesicles released by cells , which contain biomarkers , such as proteins and nucleic acids , etc.The research and application of EVs biomarkers have become one of the research hotspots internationally because EVs can sensitively reflect the pathological changes of the body and EVs detection have the advantages of non-invasive, simple sampling and real-time monitoring, comparing with tissue biopsy.This article reviews the current research status and screening strategies of EVs biomarkers aiming to encourage researchers to accelerate the development of screening and detection technologies for EVs biomarkers and translation into clinical diagnosis and treatment .