肿瘤诊断试验论著质量的初步评价
Preliminary assessment of articles reporting cancer diagnostic tests
目的促进肿瘤诊断试验评价质量的提高。方法采用整群抽样调查了《中华肿瘤杂志》90年代刊载的临床诊断试验论著。结果在调查的23篇论著中,免疫学诊断试验占比重最大,为39.1%(9/23),其次为生化学、影像学检查,分别占17.4%(4/23)、13.0%(3/23);金标准明确可靠者占82.6%(19/23),正确计算灵敏度及特异度者占60.9%(14/23),采用盲法者占39.1%(9/23);符合全部7条方法学标准者仅为4.3%(1/23),符合7条方法学标准中4条以上者为56.5%(13/23),仅符合1条方法学标准者为8.7%(2/23)。结论诊断试验评价的方法学标准受到了一定程度重视,肿瘤诊断试验论著质量有待提高与完善。
更多Objective To improve the quality of papers on clinical diagnostic tests. Methods Articles of diagnostic tests published in the Chinese Journal of Oncology in the year 1990 were surveyed by cluster sampling method. Results In the 23 articles surveyed, immunoassays constituted the largest category, accounting for 39.1% (9/23), followed by biochemical markers and radiological tests, accounting for 17.4%(4/23) and 13.0%(3/23),respectively. Of the 23 articles, 19 (82.6%) employed a well-defined “gold standard”,14 (60.9%) correctly calculated sensitivity and specificity. The interpretation of the test was stated to be “blind” in only 39.1%(9/32). In only one paper were all the seven methodologic criteria adhered. Less than 60% of the articles followed more than four of the seven methodologic criteria, and in 2 articles only one of the criteria was met with. Conclusion Although due attention has been paid to the methodologic criteria of assessing diagnostic tests, the quality of the articles surveyed needs to be improved.
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